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ML224 (NCGC00242364; ANTAG3) is a thyroid-stimulating hormone receptor TSHR counter-agonist with an IC50 of 2.1uM.
| Molecular Weight | 525.59 |
| Formula | C31H31N3O5 |
| CAS Number | 1338824-21-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related TSH Receptor Products |
|---|
| D3-βArr
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro. |
| Org41841
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. |
| VA-K-14 hydrochloride
VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM). |
| ML-109
ML-109 is a full agonist of TSHR (thyroid stimulating hormone receptor) with an EC50 of 40 nM. |
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