About 19 results found for searched term "Squalene" (0.174 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9969 | Squalene | Others |
| Squalene is a hydrocarbon containing double bond commonly found in shark liver oil, it is a biosynthetic precursor to all steroids. | ||
| M38650 | Tetrahydroxysqualene | Antibiotic |
| Tetrahydroxysqualene is a triterpene, possessing antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 10.0 μg/mL. Tetrahydroxysqualene can be isolated from the methanolic extracts of Rhus taitensis Guill. | ||
| M38829 | (E/Z)-Squalene | Apoptosis |
| (E/Z)-Squalene is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner. | ||
| M42952 | Squalene synthase-IN-1 | Others |
| Squalene synthase-IN-1 is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. | ||
| M2481 | Butenafine hydrochloride | Antibiotic |
| KP-363 | ||
| Butenafine hydrochloride is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase. | ||
| M2874 | Naftifine hydrochloride | Antibiotic |
| Naftifine is an allylamine antifungal compound for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. | ||
| M3407 | Terbinafine hydrochloride | Others |
| Terbinafine hydrochloride is a hydrochloride salt of terbinafine that is a synthetic allylamine antifungal and a squalene epoxidase inhibitor with an IC50 of 30 nM for Candida albicans. | ||
| M3896 | Ro 48-8071 | Others |
| Ro 48-8071 is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. | ||
| M4883 | RO 48-8071 fumarate | Others |
| 4012AH | ||
| Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. | ||
| M5746 | Liranaftate | Antibiotic |
| M-732 | ||
| Liranaftate is a squalene epoxidase inhibitor with anti-fungicidal activities. | ||
| M8867 | Zaragozic acid A trisodium salt | Squalene synthase |
| Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. | ||
| M9599 | NB-598 | Others |
| NB598 | ||
| NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). | ||
| M14736 | NB-598 Maleate | Others |
| NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. | ||
| M15106 | FR194738 | Others |
| FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. FR194738 is a squalene epoxidase inhibitor. | ||
| M28612 | BPH-652 | Others |
| BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation). | ||
| M28935 | YM-53601 free base | Farnesyl Transferase |
| YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. | ||
| M28936 | YM-53601 | Farnesyl Transferase |
| YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. | ||
| M28996 | Lapaquistat acetate | Others |
| TAK-475 | ||
| Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway. Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research. | ||
| M54687 | SQLE-IN-1 | PTEN |
| SQLE-IN-1 is a squalene cyclooxygenase (SQLE) inhibitor and inhibits the proliferation and migration of Huh7 cells. In addition, SQLE-IN-1 inhibits cellular cholesterol production, increases PTEN expression, and inhibits PI3K and AKT expression. | ||
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