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SQLE-IN-1 is a squalene cyclooxygenase (SQLE) inhibitor and inhibits the proliferation and migration of Huh7 cells. In addition, SQLE-IN-1 inhibits cellular cholesterol production, increases PTEN expression, and inhibits PI3K and AKT expression.
| Molecular Weight | 481.52 |
| Formula | C24H21F2N5O2S |
| CAS Number | 1019169-83-5 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PTEN Products |
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| bpV(phen)
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity. |
| Ginkgolic acid 17:1
Ginkgolic acid 17:1, a natural product isolated from Ginkgo biloba, inhibits constitutive and inducible STAT3 activation by inducing PTEN and SHP-1 tyrosine phosphatases. In addition, Ginkgolic acid C17:1 has anticancer activity. |
| bpV(phen) trihydrate
BpV (PHEN) Trihydrate, an insulin mimic, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50 of 38 nM, 343 nM, and 920 nM for PTEN, PTP-β, and PTP-1B. BpV (PHEN) TriHydrate inhibits proliferation of protozoan parasites leishmania in vitro. |
| bpV(HOpic) potassium salt
BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. |
| VO-OHpic trihydrate
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor. |
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