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Butenafine hydrochloride

Cat. No. M2481
Butenafine hydrochloride Structure
Synonym:

KP-363

Size Price Availability Quantity
1g USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Butenafine hydrochloride is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

Chemical Information
Molecular Weight 353.93
Formula C23H27N.HCl
CAS Number 101827-46-7
Form Solid
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alexander Kc Leung, et al. Tinea corporis: an updated review

[2] No authors listed. Butenafine

[3] John W Ely, et al. Diagnosis and management of tinea infections

[4] T A Syed, et al. Butenafine hydrochloride: for the treatment of interdigital tinea pedis

[5] W McNeely, et al. Butenafine

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  Catalog
Abmole Inhibitor Catalog




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