About 30 results found for searched term "SB-4" (0.013 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1794 | SB431542 | ALK |
| SB-431542 | ||
| SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM). | ||
| M1846 | SB-705498 | TRP Channel |
| SB705498 | ||
| SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. | ||
| M1983 | SB-743921 | Kinesin |
| SB-743921 is a highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5). | ||
| M2108 | SB-525334 | TGF-β Receptor |
| SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM. | ||
| M2550 | SB-505124 | TGF-β Receptor |
| Sb-505124 is a selective inhibitor of TGF-βI receptor (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. Sb-505124 also inhibits ALK7, but not ALK1, 2, 3 and 6. | ||
| M2567 | VS-5584 | PI3K |
| SB2343 | ||
| VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. | ||
| M2791 | Vilazodone hydrochloride | 5-HT Receptor |
| EMD 68843; SB659746A | ||
| KALA peptide binds oligonucleotides and disrupts cell membrane; therefore, it can be used as a DNA transfection reagent. | ||
| M2999 | SB271046 | 5-HT Receptor |
| SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes. | ||
| M3000 | Intepirdine | 5-HT Receptor |
| GSK 742457; SB-742457; RVT-101 | ||
| Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. | ||
| M3160 | Vilazodone | 5-HT Receptor |
| EMD 68843, SB 659746A | ||
| Verazodone (EMD 68843; SB 659746A) is a complex serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently being evaluated in clinical studies for major depression. | ||
| M3324 | SB408124 | OX Receptor |
| SB408124 (Tocris-1963) is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. | ||
| M3437 | Cilomilast | PDE |
| SB-207499 | ||
| Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. | ||
| M3442 | SB415286 | GSK-3 |
| SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. | ||
| M3486 | NPS-2143 | Calcium-sensing Receptor |
| SB262470 | ||
| NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. | ||
| M3488 | Eltrombopag | Thrombopoietin/Thrombin |
| SB-497115-GR, SB497115 | ||
| Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). | ||
| M2759 | Darapladib | Phospholipase |
| SB-480848 | ||
| Darapladib (SB-480848) is a selective and orally active inhibitor of Lp-PLA2 with IC50 of 0.25 nM. | ||
| M3772 | SB242084 | 5-HT Receptor |
| SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. | ||
| M3796 | SB-334867 hydrochloride | OX Receptor |
| SB 334867A HCl | ||
| SB-334867 hydrochloride is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. | ||
| M4822 | Eltrombopag Olamine | Thrombopoietin/Thrombin |
| Eltrombopag diethanolamine salt; SB-497115GR | ||
| Eltrombopag olamine is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. | ||
| M7248 | SB 200646 hydrochloride | 5-HT Receptor |
| SB-200646A | ||
| SB 200646 hydrochloride is a 5-HT 2C/2B antagonist. | ||
| M7250 | SB 204070 | Others |
| SB 204070 is a potent and selective 5-HT 4 antagonist. | ||
| M7251 | SB 204741 | Others |
| SB 204741 is a potent, selective 5-HT 2B antagonist. | ||
| M7252 | SB 205384 | GABA Receptor |
| SB 205384 is a gABA A receptor modulator; slows current decay. | ||
| M7256 | SB 221284 | Others |
| SB 221284 is a potent, selective 5-HT 2C/2B antagonist. | ||
| M7258 | SB 223412 | Neurokinin Receptor |
| Talnetant | ||
| SB 223412 is a potent, selective non-peptide NK3 antagonist. Brain penetrant. | ||
| M7263 | SB 334867 | OX Receptor |
| SB334867A free base | ||
| SB 334867 is a selective non-peptide OX 1 antagonist. | ||
| M7265 | SB 452533 | TRP Channel |
| SB 452533 is a potent TRPV1 receptor antagonist. | ||
| M7268 | SB 674042 | Others |
| SB 674042 is a potent and selective non-peptide OX 1 antagonist. | ||
| M7269 | SB 747651A dihydrochloride | Others |
| SB 747651A dihydrochloride is a potent MSK1 inhibitor; also inhibits other AGC group kinases. | ||
| M8167 | SB-204070 hydrochloride | Others |
| Selective 5-HT4 serotonin receptor antagonist. | ||
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