About 11 results found for searched term "PS48" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7989 | PS48 | Others |
| PS48 is a PDK1 (phosphoinositide-depende |
||
| M53537 | CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156) | Anti-infection |
| CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. | ||
| M4974 | GW4869 2HCl | Phospholipase |
| GW69A; GW554869A | ||
| GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. | ||
| M9005 | NPS-1034 | c-Met |
| NPS-1034 is a dual inhibitor of Axl and MET with IC50 values of 10.3 and 48 nM, respectively. | ||
| M15037 | Recombinant Mouse IP-10/CXCL10 (E. coli) | Recombinant Proteins |
| Small inducible cytokine B10; CXCL10 | ||
| Interferon inducible protein 10 (IP-10)/CXCL10 was originally thought to be an IFN-γ- inducible gene in monocytes, fibroblasts, and endothelial cells. LPS, IL-1β, TNF-α, IL-12 and virus can also induce the expression of IP-10 mRNA. Protein structure: CXCL10 (ILE22-PRO98), Accession # :Q548V9. | ||
| M21571 | Recombinant Human CD3E (Mammalian, C-mFc) | Recombinant Proteins |
| T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain | ||
| The recombinant human t cell surface glycoprotein CD3 Epsilon chain is produced by mammalian expression systems, and the target gene encoding Gln22-Thr48 is expressed at the C-terminal using mouse IgG1 Fc tag. Protein number: P07766. | ||
| M27891 | PS47 | PDK1 |
| PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48. | ||
| M27968 | PS315 | PKC |
| PS315, a derivative of PS48, is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. | ||
| M29946 | L48H37 | TLR |
| L48H37 is an analog of Curcumin with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment. | ||
| M45284 | AMG-548 dihydrochloride | p38 MAPK |
| AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
| M49631 | Tyk2-IN-3 | JAK |
| Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. | ||
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