About 12 results found for searched term "PS48" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7989 | PS48 | Others |
| PS48 is a PDK1 (phosphoinositide-depende |
||
| M53537 | CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156) | Anti-infection |
| CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. | ||
| M4974 | GW4869 2HCl | Phospholipase |
| GW69A; GW554869A | ||
| GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. | ||
| M9005 | NPS-1034 | c-Met |
| NPS-1034 is a dual inhibitor of Axl and MET with IC50 values of 10.3 and 48 nM, respectively. | ||
| M15037 | Recombinant Mouse IP-10/CXCL10 (E. coli) | Cytokines and Growth Factors |
| Small inducible cytokine B10; CXCL10 | ||
| Interferon inducible protein 10 (IP-10)/CXCL10 was originally thought to be an IFN-γ- inducible gene in monocytes, fibroblasts, and endothelial cells. LPS, IL-1β, TNF-α, IL-12 and virus can also induce the expression of IP-10 mRNA. Protein structure: CXCL10 (ILE22-PRO98), Accession # :Q548V9. | ||
| M21571 | Recombinant Human CD3E (HEK293, C-mFc) | Cytokines and Growth Factors |
| T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain | ||
| The recombinant human t cell surface glycoprotein CD3 Epsilon chain is produced by mammalian expression systems, and the target gene encoding Gln22-Thr48 is expressed at the C-terminal using mouse IgG1 Fc tag. Protein number: P07766. | ||
| M27891 | PS47 | PDK1 |
| PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48. | ||
| M27968 | PS315 | PKC |
| PS315, a derivative of PS48, is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. | ||
| M29946 | L48H37 | TLR |
| L48H37 is an analog of Curcumin with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment. | ||
| M45284 | AMG-548 dihydrochloride | p38 MAPK |
| AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
| M49631 | Tyk2-IN-3 | JAK |
| Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. | ||
| M58570 | AF488 NHS ester TEA | Fluorescent Dye |
| AF488 NHS ester TEA is an amine specific fluorescence probe. AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively. | ||
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