L48H37

Cat. No. M29946

All AbMole products are for research use only, cannot be used for human consumption.

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Quality Control & Documentation

Purity: ≥99.0%
COA
MSDS

Product Information

Biological Activity

L48H37 is an analog of Curcumin with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment.

Chemical Information

Molecular Weight	483.55
Formula	C27H33NO7
CAS Number	343307-76-6
Form	Solid
Solubility (25°C)	DMSO 50 mg/mL (ultrasonic)
Storage	4°C, protect from light

References

[1] Ko-Hsiu Lu, et al. Molecules. Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells' Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway

[2] Si-Si Li, et al. World J Gastrointest Oncol. KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma

[3] No authors listed. J Pharmacol Exp Ther. Correction to "Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2"

[4] Chen Feng, et al. Mol Carcinog. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells

[5] Yi Wang, et al. J Pharmacol Exp Ther. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2

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L48H37

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