About 33 results found for searched term "MEK inhibitor" (0.104 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14169 | GDC-0623 | MEK |
| RG 7421; MEK inhibitor 1 | ||
| GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). | ||
| M14170 | MEK inhibitor | MEK |
| MEK inhibitor is a potent MEK inhibitor with antitumor potency. | ||
| M49714 | MEK1 Derived Peptide Inhibitor 1 | ERK |
| MEK1 Derived Peptide Inhibitor 1 is a peptide inhibitor. | ||
| M49718 | Myristoyl-MEK1 Derived Peptide Inhibitor 1 | ERK |
| Myristoyl-MEK1 Derived Peptide Inhibitor 1 is the myristoylated form of the MEK1 Derived Peptide Inhibitor 1. | ||
| M1652 | AS703026 | MEK |
| MSC1936369B,Pimasertib | ||
| AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo. | ||
| M1661 | AZD6244 | MEK |
| Selumetinib, ARRY-142886 | ||
| AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM. | ||
| M1662 | AZD8330 | MEK |
| ARRY-424704, ARRY-704 | ||
| AZD8330 (ARRY-424704) is a novel, selective, highly efficacious, uncompetitive MEK inhibitor with an IC50 of 7 nM. | ||
| M1744 | ARRY-162 (Binimetinib) | MEK |
| MEK-162; Binimetinib; ARRY-438162 | ||
| ARRY-162 (MEK-162; Binimetinib) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively. | ||
| M1750 | TAK-733 | MEK |
| TAK-733 is a potent and selective MEK allosteric site inhibitor with IC50 of 3.2nM for the treatment of cancer. | ||
| M1759 | GSK1120212 (Trametinib) | MEK |
| JTP-74057, GSK212 | ||
| Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. | ||
| M1763 | Mirdametinib (PD0325901) | MEK |
| Mirdametinib；PD325901 | ||
| Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. | ||
| M1905 | PD318088 | MEK |
| PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. | ||
| M1957 | BMS-536924 | IGF-1R |
| Bms-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50 of 100 nM and 73 nM, respectively. It also showed moderate inhibitory activity against Mek, Fak and Lck, but almost no inhibitory activity against Akt1 and MAPK1/2. | ||
| M2915 | PD 198306 | MEK |
| PD 198306 is a cell-permeable and highly selective MEK inhibitor with IC50 of 8 nM. | ||
| M3626 | Cobimetinib (GDC-0973) | MEK |
| Cobimetinib ; XL518 | ||
| Cobimetinib (GDC-0973, RG7420) is an effective, selective, oral MEK1 inhibitor with an IC50 of 4.2 nM against MEK1. In addition, Cobimetinib is an inhibitor of Akt. | ||
| M5236 | BI-847325 | MEK |
| BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. | ||
| M8046 | PD-184161 | Others |
| PD-184161 is a MEK inhibitor. | ||
| M9014 | RO4987655 | MEK |
| CH4987655 | ||
| RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM. | ||
| M10369 | RO5126766 (VS-6766) | MEK |
| CH5126766; VS 6766; Avutometinib | ||
| RO5126766 (CH5126766, VS 6766) is a first-in-class dual MEK/RAF inhibitor with IC50 values of 8.2 nM, 19 nM, 56 nM and 160 nM for BRAF V600E, BRAF, CRAF and MEK1, respectively. | ||
| M10503 | GW284543 (UNC10225170) | MEK |
| UNC10225170 | ||
| GW284543 (UNC10225170) is a selective MEK5 inhibitor, which reduces pERK5 and decreases endogenous MYC protein. | ||
| M11250 | Zapnometinib | MEK |
| PD0184264; ATR-002 | ||
| Zapnometinib (PD0184264), an active metabolite of CI-1040, is an MEK inhibitor with an IC50 value of 5.7 nM. Zapnometinib has antiviral and antibacterial activity against influenza viruses. | ||
| M14168 | Cobimetinib hemifumarate | MEK |
| GDC-0973 hemifumarate; XL-518 hemifumarate | ||
| Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. In addition, Cobimetinib is an inhibitor of Akt. | ||
| M14171 | Selumetinib sulfate | MEK |
| AZD6244 sulfate; ARRY-142886 sulfate | ||
| Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. | ||
| M14172 | Trametinib (DMSO solvate) | MEK |
| GSK-1120212 (DMSO solvate); JTP-74057 (DMSO solvate) | ||
| Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. | ||
| M20028 | WAY-114228 | MEK |
| WAY-114228 is a MEK1 inhibitor. | ||
| M21071 | MAP855 | MEK |
| MAP855 is a potent, selective and orally effective ATP-competitive MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 inhibits wild-type and mutant MEK1/2 equally. | ||
| M21987 | Cobimetinib racemate | MEK |
| Cobimetinib racemate is the racemate of Cobimetinib, a potent, selective, orally available MEK1 inhibitor with an IC50 for MEK1 inhibition of 4.2 nM.In addition, Cobimetinib is an Akt inhibitor. | ||
| M27786 | U0126 | MEK |
| U0126 is a potent, non-ATP-competitive, selective inhibitor of MEK1 and MEK2 with IC50s of 72 nM and 58 nM, respectively.In addition, U0126 is an autophagy and mitophagy inhibitor and inhibits LPA-induced entosis. | ||
| M28882 | EBI-1051 | MEK |
| EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM. | ||
| M29856 | MEK-IN-4 | MEK |
| MEK-IN-4 is a MEK inhibitor. MEK-IN-4 can be used for the research of inflammatory disorders and cancers. | ||
| M42142 | GW284543 hydrochloride | MEK |
| GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. | ||
| M42145 | MEK-IN-6 hydrate | MEK |
| MEK-IN-6 hydrate is a MEK inhibitor. | ||
| M43554 | MEK-IN-6 | ERK |
| MEK-IN-6 is a MEK inhibitor. | ||
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