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MAP855

Cat. No. M21071

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MAP855  Structure

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Quality Control & Documentation
Biological Activity

MAP855 is a potent, selective and orally effective ATP-competitive MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 inhibits wild-type and mutant MEK1/2 equally.

Chemical Information
Molecular Weight 564.97
Formula C28H23ClF2N6O3
CAS Number 1660107-77-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ramulu Poddutoori, et al. J Med Chem. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action

[2] Luca Hegeds, et al. Cancers (Basel). Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation

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  Catalog
Abmole Inhibitor Catalog




Keywords: MAP855 supplier, MEK, inhibitors, activators

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