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GW284543 (UNC10225170)

Cat. No. M10503
GW284543 (UNC10225170) Structure
Synonym:

UNC10225170

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 170  USD170 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GW284543 (UNC10225170) is a selective MEK5 inhibitor, which reduces pERK5 and decreases endogenous MYC protein.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 372.42
Formula C23H20N2O3
CAS Number 790186-68-4
Purity >99%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

[1] Angelina V Vaseva, et al. Cancer Cell . KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GW284543 (UNC10225170), UNC10225170 supplier, MEK, inhibitors

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