About 12 results found for searched term "LE135" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13345 | LE135 | RAR/RXR |
| LE135 is an effective RAR antagonist, which can selectively bind RARα (Ki is 1.4 μM) and RARβ (Ki is 220 nM), and has a higher affinity for RARβ. The LE135 is highly selective for RARγ, RXRα, RXRβ and RXRγ. LE135 is also a vitamin A acid receptor antagonist. | ||
| M1729 | H-89 Dihydrochloride | PKA |
| H-89 2HCl | ||
| H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM. | ||
| M2806 | LDN-212854 | ALK |
| BMP Inhibitor III | ||
| LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively. | ||
| M9678 | SAR407899 | ROCK |
| SAR407899 is a potent and selective, ATP-competitive ROCK inhibitor with IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. | ||
| M11473 | BAY 2666605 | Others |
| BAY 2666605 is an oral active PDE3A and PDE3B inhibitor with IC50 of 87 nM and 50 nM, respectively. BAY 2666605 is a pDE3A-SLFN12 compound inducer (WO2019025562A1; Example, 135). | ||
| M11489 | Recombinant Human MCP-1/CCL2 (E. coli) | Cytokines and Growth Factors |
| MCAF; JE; Monocyte Chemotactic Protein-1; CCL2; MCP1 | ||
| The EC50 value of human MCP-1/CCL2 on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR2 cells (human Gα15 and human CCR2 stably expressed in CHO-K1 cells) is less than 1.0 μg/ml. Accession # : P13500. | ||
| M13732 | SAR407899 hydrochloride | ROCK |
| SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. | ||
| M21393 | TCMDC-135051 | Others |
| TCMDC-135051 is a highly selective and potent inhibitor of the protein kinase PfCLK3 with low off-target toxicity.TCMDC-135051 prevents trophozoite to lytic transition, disrupts transcription and reduces transmission to mosquito vectors.TCMDC-135051 has antiparasitic activity (EC50=320 nM). | ||
| M27804 | BI-135585 | Hydroxysteroid dehydrogenase |
| BI-135585 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor with an IC50 of 13 nM. BI-135585 exhibits >1000-fold selectivity over other hydroxysteroid dehydrogenases. BI-135585 can be used for type 2 diabetes research. | ||
| M27841 | PQCA | AChR/AChE |
| PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease. | ||
| M28930 | VY-3-135 | Others |
| VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer. | ||
| M29734 | PW0787 | GPR/FFAR |
| PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior. | ||
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