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BAY 2666605

Cat. No. M11473
BAY 2666605  Structure
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Quality Control
  • Current batch:
  • Purity N/A
  • COA
  • MSDS
Biological Activity

BAY 2666605 is an oral active PDE3A and PDE3B inhibitor with IC50 of 87 nM and 50 nM, respectively. BAY 2666605 is a pDE3A-SLFN12 compound inducer (WO2019025562A1; Example, 135).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 352.28
Formula C17H12F4N2O2
CAS Number 2275774-60-0
Purity N/A
Solubility N/A
Storage at -20°C
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Antide

Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2

NE-CARBOXYMETHYL-L-LYSINE

NE-CARBOXYMETHYL-L-LYSINE

  Catalog
Abmole Inhibitor Catalog




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