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BI-135585 

Cat. No. M27804

All AbMole products are for research use only, cannot be used for human consumption.

BI-135585  Structure

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Quality Control & Documentation
Biological Activity

BI-135585 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor with an IC50 of 13 nM. BI-135585 exhibits >1000-fold selectivity over other hydroxysteroid dehydrogenases. BI-135585 can be used for type 2 diabetes research.

Chemical Information
Molecular Weight 460.56
Formula C28H32N2O4
CAS Number 1114561-85-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Linghang Zhuang, et al. Bioorg Med Chem. Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

[2] Bachir Latli, et al. J Labelled Comp Radiopharm. Potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 labeled with carbon-13 and carbon-14

[3] Bradford S Hamilton, et al. Eur J Pharmacol. Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys

[4] S Freude, et al. Diabetes Obes Metab. Safety, pharmacokinetics and pharmacodynamics of BI 135585, a selective 11β-hydroxysteroid dehydrogenase-1 (HSD1) inhibitor in humans: liver and adipose tissue 11β-HSD1 inhibition after acute and multiple administrations over 2 weeks

[5] Bradford S Hamilton, et al. Eur J Pharmacol. Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

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Keywords: BI-135585  supplier, Hydroxysteroid dehydrogenase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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