| Cat.No. | Name | Information |
|---|---|---|
| M8976 | ASP9521 | ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). |
| M2492 | Carbenoxolone Sodium | Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels. |
| M40990 | ARO-HSD | ARO-HSD is an siRNA and also an inhibitor of 17β-HSD13 that can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M40977 | ALN-HSD | ALN-HSD is an siRNA and also an inhibitor of 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13), which can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M30757 | ABT-384 | ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD). |
| M30196 | SCH-451659 | SCH-451659 is an inhibitor of 17β-hydroxysteroid dehydrogenases (17β-HSDs) for cancer research. |
| M29847 | BI‑3231 | BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases. |
| M28211 | SKI2852 | SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively. |
| M27804 | BI-135585 | BI-135585 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor with an IC50 of 13 nM. BI-135585 exhibits >1000-fold selectivity over other hydroxysteroid dehydrogenases. BI-135585 can be used for type 2 diabetes research. |
| M27787 | AMG-221 | AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays. AMG-221 can be used for the research of type 2 diabetes. |
| M27656 | AZD 4017 | AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC50 of 7 nM. |
| M21098 | INCB13739 | INCB13739 is an orally effective, selective and tissue-specific 11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor with IC50 values of 3.2 nM (11β-HSD1 enzyme) and 1.1 nM (11β-HSD1 PBMC), respectively.INCB13739 can be used in type 2 diabetes mellitus (T2DM) and obesity studies. |
| M14664 | BVT-14225 | BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM. |
| M7671 | BMS-823778 | BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehyd |
| M7670 | BMS-770767 | BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I (11β-HSD1), which is a regulator of glucocorticoid activity and thought to play a possible role in metabolic syndrome. |
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