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ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD).
| Molecular Weight | 493.56 |
| Formula | C25H34F3N5O2 |
| CAS Number | 868623-40-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 31.25 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light |
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