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BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I (11β-HSD1), which is a regulator of glucocorticoid activity and thought to play a possible role in metabolic syndrome. 11β-HSD1 can convert cortisol to the inactive metabolite cortisone, or catalyze the reverse reaction, converting inactive cortisone into active cortisol in cells. BMS-770767 was in clinical trials for hypercholesterolemia and Type 2 diabetes.
| Molecular Weight | 355.82 |
| Formula | C19H18ClN3O2 |
| CAS Number | 1875067-34-7 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Hydroxysteroid dehydrogenase Products |
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