About 30 results found for searched term "IST-3" (0.034 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2297 | Devimistat (CPI-613) | Dehydrogenase |
| Devimistat | ||
| Devimistat (CPI-613) inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. | ||
| M4647 | Phorbol 12-myristate 13-acetate | PKC |
| PMA, TPA, 12-O-tetradecanoyl-phorbol-13-acetate; 12,13-tetradecanoyl phorbol acetate | ||
| Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. | ||
| M4786 | Aristolochic acid A | NF-κB |
| Aristolochic acid I; TR 1736 | ||
| Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. | ||
| M10121 | DSPC | Cell Transfection |
| 1,2-Distearoyl-sn-glycero-3-phosphocholine | ||
| 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system. | ||
| M10255 | Phosphatidylserine | Others |
| 1,2-Distearoyl-sn-3-glycerophosphoserine | ||
| M10447 | DMPC | Cell Transfection |
| 1,2-Dimyristoyl-sn-glycero-3-phosphocholine; Dimyristoyl phosphatidylcholine | ||
| 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) has the ability to enhance the constancy and in vitro antiproliferative effect of carmofur. | ||
| M11332 | diABZI trihydrochloride | STING |
| Diamidobenzimidazole STING Agonist-1 3HCl | ||
| diABZI (STING agonist-1) trihydrochloride is a selective agonist of interferon gene-stimulated receptor (STING), with EC50 scores of 130 nM and 186 nM in mice and humans, respectively. | ||
| M14037 | Orexin receptor antagonist 3 | OX Receptor |
| Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist. | ||
| M14124 | STING agonist-3 | STING |
| STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. | ||
| M21193 | SAR247799 | S1P Receptor |
| S1P1 agonist 3 | ||
| The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways. | ||
| M21677 | Recombinant Human Follistatin 288 (HEK293, C-6His) | Cytokines and Growth Factors |
| FST; follistatin isoform FST317 | ||
| Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Recombinant Human Follistatin/FST is produced by Mammalian expression system and the target gene encoding Gly30-Asn317 is expressed with a 6His tag at the C-terminus. | ||
| M25498 | 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine | Cell Transfection |
| DSPE | ||
| 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis of liposomes. | ||
| M25503 | 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium | Cell Transfection |
| 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is the component of liposomes for drug delivery. | ||
| M27994 | TLR7 agonist 3 | TLR |
| TLR7 agonist 3 (Compound 2) is a potent agonist of toll-like receptor 7 (TLR7). TLR7 has an important role in immune activation processes and represents an emerging agent discovery target for the development of immunomodulators. | ||
| M29626 | P2X3 antagonist 34 | P2 Receptor |
| P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25 nM, 92 nM and 126 nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect. | ||
| M29958 | AR antagonist 3 | Androgen Receptor |
| AR antagonist 3 is a potent and selective androgen receptor (AR) antagonist with an IC50 of 0.47 µM. AR antagonist 3 exhibits a dose-dependent decrease of the FRET signal (IC50= 18.05 μM). AR antagonist 3 shows effective inhibition on tumor growth when administered intratumorally. | ||
| M30911 | CB2 receptor agonist 3 | Cannabinoid |
| GP2a | ||
| CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells. | ||
| M31407 | IST-3 | Others |
| IST-3 is a glycolysis inhibitor that can be used in studies related to multiple sclerosis (MS). | ||
| M40663 | A2A receptor antagonist 3 | Adenosine Receptor |
| A2A receptor antagonist 3 is an adenosine receptor A2a antagonist with a Ki of 0.4 nM. It binds to A2b, A1, and A3 receptors with Ki values of 37, 107, and 1467 nM, respectively. | ||
| M41079 | Histatin-3 | Antibiotic |
| Histatin-3, a 32 amino acid peptide, possesses powerful antimicrobial properties. | ||
| M41280 | AHR agonist 3 | Apoptosis |
| AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. | ||
| M41562 | TLR7 agonist 13 | Nucleoside Antimetabolite/Analog |
| TLR7 agonist 13 is a guanosine analog. | ||
| M41730 | 5-HT2A receptor agonist-3 | 5-HT Receptor |
| 5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM. | ||
| M41740 | 5-HT2C agonist-3 free base | 5-HT Receptor |
| 5-HT2C agonist-3 ((+)-19) free base is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). | ||
| M41743 | 5-HT2C agonist-3 | 5-HT Receptor |
| 5-HT2C agonist-3 ((+)-19) is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). | ||
| M41760 | A1/A3 AR antagonist 3 | Adenosine Receptor |
| A1/A3 AR antagonist 3 is an A1R/A3R dual antagonist with high affinity at low-micromolar to low-nanomolar. | ||
| M41835 | GLP-1 receptor agonist 13 | GLP Receptor |
| GLP-1 receptor agonist 13 is a glucagon GLP-1 receptor agonist with EC50 of 76 nM. | ||
| M41848 | H4R antagonist 3 | Histamine Receptor |
| H4R antagonist 3 is a histamine-4 receptor antagonist with an EC50 of ＜10 mM. | ||
| M41854 | LTB4 antagonist 3 | Leukotriene Receptor |
| LTB4 antagonist 3 is a leukotriene B4 (LTB4) antagonist with an IC50 value of 477 nM. | ||
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