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DSPC

Cat. No. M10121
DSPC Structure
Synonym:

1,2-Distearoyl-sn-glycero-3-phosphocholine

Size Price Availability Quantity
100mg USD 52  USD52 In stock
500mg USD 166  USD166 In stock
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Quality Control & Documentation
Biological Activity

1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.

Chemical Information
Molecular Weight 790.15
Formula C44H88NO8P
CAS Number 816-94-4
Solubility (25°C) Ethanol 10 mg/mL (ultrasonic and warming)
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Othmene Benazieb, et al. Phys Rev E. Rheology of sliding leaflets in coarse-grained DSPC lipid bilayers

[2] Sagar Kamble, et al. Chem Phys Lipids. Nano-mechanical characterization of asymmetric DLPC/DSPC supported lipid bilayers

[3] Sevgi Kilic, et al. Colloids Surf B Biointerfaces. Phase behavior of DSPC/PEG 40 St mixtures at higher emulsifier contents

[4] Debabrata Panda, et al. Ultrason Sonochem. Recent advancements in the sonophotocatalysis (SPC) and doped-sonophotocatalysis (DSPC) for the treatment of recalcitrant hazardous organic water pollutants

[5] Jayesh A Kulkarni, et al. Nanomedicine. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA

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