About 12 results found for searched term "IM-12" (0.053 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2320 | 17-AAG (Tanespimycin) | HSP |
| Tanespimycin; 17AAG; NSC 330507; CP 127374 | ||
| 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. | ||
| M3691 | IM-12 | GSK-3 |
| IM-12 is a potent and selective GSK-3β inhibitor with IC50 of 53 nM, which also enhances canonical Wnt signalling. | ||
| M1629 | Ramucirumab | VEGFR/PDGFR |
| LY3009806; IMC-1121B | ||
| Ramucirumab is a direct VEGFR2 antagonist, that binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). | ||
| M5191 | C-DIM12 | Apoptosis |
| DIM-C-pPhCl | ||
| C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells. | ||
| M10941 | Tapinarof | Aryl hydrocarbon Receptor |
| WBI-1001; Benvitimod; GSK2894512 | ||
| Tapinarof (WBI-1001) is a Frist in class aromatic hydrocarbon receptor (AhR) agonist with EC50 of 13 nM. Tapinarof reduced skin inflammation in mice. It can effectively inhibit inflammatory cytokines, regulate skin barrier protein expression and antioxidant activity. | ||
| M14105 | Limaprost | PGE synthase |
| 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206 | ||
| Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research. | ||
| M17479 | Drim-7-ene-11,12-diol acetonide | Sesquiterpenoids |
| Drim-7-ene-11,12-diol acetonide | ||
| M24538 | Olaratumab | VEGFR/PDGFR |
| IMC-3G3; LY3012207 | ||
| Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity. | ||
| M25306 | Cixutumumab | IGF-1R |
| IMC-A12; NSC742460 | ||
| Cixutumumab (IMC-A12) is a humanized anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer. | ||
| M38782 | Antimalarial agent 12 | Parasite |
| Antimalarial agent 12 is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. | ||
| M51631 | Competence-Stimulating Peptide-12261 | Others |
| Competence-Stimulating Peptide-12261, a sixteen peptide, is a fragment of competence-stimulating peptide. | ||
| M57985 | Fondaparinux sodium Impurity 12 | Others |
| Fondaparinux sodium Impurity 12 | ||
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