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Cixutumumab

Cat. No. M25306

All AbMole products are for research use only, cannot be used for human consumption.

Cixutumumab Structure
Synonym:

IMC-A12; NSC742460

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Quality Control & Documentation
Biological Activity

Cixutumumab (IMC-A12) is a humanized anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer.

Chemical Information
CAS Number 947687-12-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Helen Imrie, et al. Adipocyte. Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity

[2] Hongxin Cao, et al. Clin Drug Investig. Adverse Events and Efficacy of Cixutumumab in Phase II Clinical Trials: A systematic Review and Meta-Analysis

[3] Arun Rajan, et al. Lancet Oncol. Cixutumumab for patients with recurrent or refractory advanced thymic epithelial tumours: a multicentre, open-label, phase 2 trial

[4] Eric K Rowinsky, et al. Curr Drug Targets. Blockade of insulin-like growth factor type-1 receptor with cixutumumab (IMC-A12): a novel approach to treatment for multiple cancers

[5] Kevin P McKian, et al. Expert Opin Investig Drugs. Cixutumumab

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Keywords: Cixutumumab, IMC-A12; NSC742460 supplier, IGF-1R, inhibitors, activators

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