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IM-12

Cat. No. M3691

All AbMole products are for research use only, cannot be used for human consumption.

IM-12 Structure
Size Price Availability Quantity
10mg USD 70  USD70 In stock
50mg USD 280  USD280 In stock
100mg USD 500  USD500 In stock
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Quality Control & Documentation
Biological Activity

IM-12 is a potent and selective GSK-3β inhibitor with IC50 of 53 nM, which also enhances canonical Wnt signalling. IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly in hNPCs. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. IM-12 has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

Protocol (for reference only)
Cell Experiment
Cell lines ReNcell VM cells
Preparation method To measure viable cells, using CASY technology with the appropriate program to analyze 50-100 μL of cell suspension .Adding ReNcell VM cells are at a defined cell number and proliferated for 24 h. Then changing the medium to proliferation medium with added substances at indicated concentrations. Determining the cell number every 24 h. Exposing cells to the added drugs during the whole experiment, whereas changing the media every 24 h.
Concentrations 3 μM
Incubation time 72 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 377.41
Formula C22H20FN3O2
CAS Number 1129669-05-1
Solubility (25°C) DMSO 60 mg/mL
Ethanol 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Schmöle AC, et al. Bioorg Med Chem. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.

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  Catalog
Abmole Inhibitor Catalog




Keywords: IM-12 supplier, GSK-3, inhibitors, activators

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