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Cat. No. M24538
Olaratumab Structure

IMC-3G3; LY3012207

Size Price Availability
1mg USD 400  USD400 3-4 Weeks
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Quality Control & Documentation
Biological Activity

Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity.

Chemical Information
CAS Number 1024603-93-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] No authors listed. Olaratumab

[2] No authors listed. Olaratumab

[3] Georgios Antoniou, et al. Eur J Cancer. Olaratumab in soft tissue sarcoma - Current status and future perspectives

[4] Alexandra Pender, et al. Future Oncol. Olaratumab for the treatment of soft-tissue sarcoma

[5] Matt Shirley. Drugs. Olaratumab: First Global Approval

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Keywords: Olaratumab, IMC-3G3; LY3012207 supplier, VEGFR/PDGFR, inhibitors, activators

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