About 14 results found for searched term "HAP-1" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28265 | Delavirdine | HIV Protease |
| U 90152; BHAP-U 90152 | ||
| Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs. | ||
| M50459 | HAP-1 | Others |
| HAP-1 is a synovial-targeted transduction peptide. | ||
| M7353 | Tamoxifen | Estrogen Receptor |
| ICI47699; Z-Tamoxifen; trans-Tamoxifen | ||
| Tamoxifen is an orally active, selective estrogen receptor partial agonist/antagonist. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively. | ||
| M9877 | Rhapontigenin | Cytochrome P450 (e.g. CYP17) |
| Protigenin | ||
| Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM. | ||
| M10121 | DSPC | Cell Transfection |
| 1,2-Distearoyl-sn-glycero-3-phosphocholine | ||
| 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system. | ||
| M11181 | 2,5-Dihydroxyacetophenone | ERK |
| DHAP, 2-Acetylhydroquinone, Quinacetophenone | ||
| 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers used in food flavoring. 2',5'-Dihydroxyacetophenone significantly inhibits the production of NO by inhibiting the expression of iNOS. 2',5'-Dihydroxyacetophenone significantly reduces the expression levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways. | ||
| M11512 | CBL0137 hydrochloride | p53 |
| Curaxin-137 hydrochloride; CBL-C137 hydrochloride | ||
| CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively. | ||
| M14980 | Rhapontigenin 3'-O-glucoside | Others |
| Rhapontigenin 3'-O-glucoside is a derivative of Rhapontigenin. Rhapontigenin is a potent inactivator of human P450 1A1 and is a good candidate for a cancer chemopreventive agent. | ||
| M27749 | MAC13243 | Antibiotic |
| MAC13243, an antibacterial agent, is an inhibitor of bacterial lipoprotein targeting chaperone, LolA. MAC13243 is an antibacterial agent with Gram-negative selectivity. | ||
| M28488 | PU-H54 | HSP |
| PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy. | ||
| M29144 | Claficapavir | HIV Protease |
| A1752 | ||
| Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1. | ||
| M29400 | JI051 | Notch |
| JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity. | ||
| M49438 | Opiorphin | Neprilysin (NEP) |
| Opiorphin is an opioid peptide that simultaneously inhibits the activity of two enkephalinolytic enzymes, human neutral exopeptide endogenous peptidase hNEP (EC 3.4.24.11) and human exoamino peptidase hAP-N (EC 3.4.11.2). | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
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