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Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM. Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively. Rhapontigenin inhibits ADP- and collagen-induced platelet aggregation with IC50 values of 4 and 70 μg/ml, respectively. Rhapontigenin demonstrates a strong inhibitory activity on the 13-hexosaminidase release induced by DNP-BSA, it exhibits IC50 value of 0.03 mM in RBL 2H3 cells. In vivo, Rhapontigenin (25mg/kg; i.p.) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen.
| Molecular Weight | 258.27 |
| Formula | C15H14O4 |
| CAS Number | 500-65-2 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related Cytochrome P450 (e.g. CYP17) Products |
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| (3S,5S)-Atorvastatin sodium salt
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