About 23 results found for searched term "Guanylate Cyclase" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5932 | Riociguat (BAY 63-2521) | Guanylate Cyclase |
| BAY 632521 | ||
| Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the research of ipulmonary hypertension. | ||
| M7526 | Linaclotide | Guanylate Cyclase |
| Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. | ||
| M10103 | Plecanatide | Guanylate Cyclase |
| Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. | ||
| M10118 | Vericiguat | Guanylate Cyclase |
| BAY1021189; Verquvo | ||
| Vericiguat is a potent and orally available stimulator of guanylate cyclase (sGC). | ||
| M13989 | Cinaciguat | Guanylate Cyclase |
| BAY 58-2667 | ||
| Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure. | ||
| M21131 | Runcaciguat | Guanylate Cyclase |
| Runcaciguat is an orally available soluble guanylate cyclase promoter that can be combined with selective partial adenosine A1 receptor agonists for the study of cardiovascular and renal disease. | ||
| M21391 | Praliciguat | Guanylate Cyclase |
| IW-1973 | ||
| Praliciguat (IW-1973) is a potent, orally available promoter of soluble guanylate cyclase, which enhances the NO signaling pathway and is a vasodilator. In HEK-293 cells, Praliciguat (IW-1973) was able to stimulate sGC with an EC50 value of 197 nM. | ||
| M24702 | Indusatumab | Others |
| 5F9 Monoclonal antibody | ||
| Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody. | ||
| M24707 | Indusatumab vedotin | Drug-Linker Conjugates for ADC |
| MLN0264; TAK-264 | ||
| Indusatumab vedotin (MLN-0264; AKT-264) is an antibody-drug conjugate (ADC) consisting of the human anti-guanylate cyclase C (GCC) antibody linked to a microtubule-disruptor Monomethyl auristatin . Indusatumab vedotin has anti-proliferative effects on pancreas cancer cell lines. Indusatumab vedotin arrests cell cycle at G2/M phase, and induces apoptosis. | ||
| M28724 | Olinciguat | Guanylate Cyclase |
| IW-1701 | ||
| Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay. | ||
| M28949 | (Rac)-MGV354 | Guanylate Cyclase |
| (Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively. | ||
| M29395 | Mosliciguat | Guanylate Cyclase |
| BAY 1237592 | ||
| Mosliciguat is a guanylate cyclase activator. | ||
| M29701 | Ataciguat | Guanylate Cyclase |
| HMR-1766 | ||
| Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects. | ||
| M30877 | LY83583 | Guanylate Cyclase |
| LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM. | ||
| M31364 | Dolcanatide | Guanylate Cyclase |
| Dolcanatide is an orally active uridine analog that is also a guanylate cyclase C (GC-C) agonist with anti-inflammatory activity and may be used in studies related to inflammatory bowel disease. | ||
| M49830 | Plecanatide acetate | Guanylate Cyclase |
| Plecanatide acetate is an analog of urinary guanosine protein and an orally active guanylate cyclase-C (GC-C) receptor agonist with an EC50 value of 190 nM in T84 cells.Additionally, Plecanatide acetate has been shown to have anti-inflammatory activity and can be used in studies related to chronic idiopathic constipation. In addition, Plecanatide acetate has anti-inflammatory activity and can be used in studies related to chronic idiopathic constipation. | ||
| M50199 | BAY-3283142 | Guanylate Cyclase |
| BAY-3283142 is a soluble guanylate cyclase complex (sGC) stimulator for studies related to hypertension and chronic kidney disease. | ||
| M53113 | Guanylin(human) | Guanylate Cyclase |
| Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. | ||
| M54169 | MM 419447 | Guanylate Cyclase |
| MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. | ||
| M56208 | BAY-747 | Guanylate Cyclase |
| BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). | ||
| M56206 | Zagociguat | Guanylate Cyclase |
| Zagociguat is the stimulator of soluble guanylate cyclase. | ||
| M56205 | 2-Chloro-ATP | Guanylate Cyclase |
| 2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production. | ||
| M56204 | CFM 1571 hydrochloride | Guanylate Cyclase |
| CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. | ||
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