Mosliciguat is a guanylate cyclase activator.
| Molecular Weight | 729.18 |
| Formula | C41H36ClF3N2O5 |
| CAS Number | 2231749-54-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Guanylate Cyclase Products |
|---|
| MM 419447
MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. |
| Guanylin(human)
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. |
| Cenderitide
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). |
| Prepro-ANF (56-92), human
Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. |
| Guanylin (mouse, rat)
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. |
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