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Olinciguat

Cat. No. M28724

All AbMole products are for research use only, cannot be used for human consumption.

Olinciguat Structure
Synonym:

IW-1701

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Quality Control & Documentation
Biological Activity

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

Chemical Information
Molecular Weight 509.39
Formula C21H16F5N7O3
CAS Number 1628732-62-6
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Boris Tchernychev, et al. Br J Pharmacol. Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease

[2] Peter Sandner, et al. Expert Opin Ther Pat. Soluble guanylate cyclase stimulators and their potential use: a patent review

[3] Daniel P Zimmer, et al. Front Pharmacol. Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

[4] E S Buys, et al. Nitric Oxide. Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

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Keywords: Olinciguat, IW-1701 supplier, Guanylate Cyclase, inhibitors, activators

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