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Praliciguat (IW-1973) is a potent, orally available promoter of soluble guanylate cyclase, which enhances the NO signaling pathway and is a vasodilator. In HEK-293 cells, Praliciguat (IW-1973) was able to stimulate sGC with an EC50 value of 197 nM.
| Molecular Weight | 534.36 |
| Formula | C21H14F8N6O2 |
| CAS Number | 1628730-49-3 |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Guanylate Cyclase Products |
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| BAY-747
BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). |
| MCUF-651
MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). |
| Zagociguat
Zagociguat is the stimulator of soluble guanylate cyclase. |
| 2-Chloro-ATP
2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production. |
| CFM 1571 hydrochloride
CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. |
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