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Plecanatide

Cat. No. M10103
Plecanatide Structure
Size Price Availability Quantity
2mg USD 130  USD130 In stock
5mg USD 225  USD225 In stock
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Quality Control & Documentation
Biological Activity

Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).

Chemical Information
Molecular Weight 1681.89
Formula C65H104N18O26S4
CAS Number 467426-54-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Philip B Miner. Expert Rev Gastroenterol Hepatol. Plecanatide for the treatment of constipation-predominant irritable bowel syndrome

[2] No authors listed. Plecanatide

[3] Gabrio Bassotti, et al. Expert Rev Clin Pharmacol. Plecanatide for the treatment of chronic idiopathic constipation in adult patients

[4] No authors listed. Plecanatide

[5] Zaina T Al-Salama, et al. Drugs. Plecanatide: First Global Approval

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Keywords: Plecanatide supplier, Guanylate Cyclase, inhibitors, activators


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