About 20 results found for searched term "DAPT" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1746 | DAPT | Gamma-secretase/Beta-secretase |
| GSI-IX | ||
| DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling. | ||
| M1938 | Daptomycin | Antibiotic |
| Cubicin, Dapcin | ||
| Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. | ||
| M6406 | Adaptaquin | Others |
| Adaptaquin is a hIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant. | ||
| M20858 | DAPTA | CCR |
| D-Ala-peptide T-amide, peptide T | ||
| DAPTA is a water soluble potent, selective CCR5 inhibitor which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5. | ||
| M4529 | Rosavin | Others |
| Rosavin comes from R. Rosea. Rosavin has shown antidepressant, adaptogenic and antianxiety - like effects in mouse models. | ||
| M5062 | Polyinosinic acid: polycytidylic acid (poly I:C) | TLR |
| poly I:C | ||
| Polyinosinic acid: polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. | ||
| M8767 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. | ||
| M9602 | Atamparib (RBN-2397) | PARP |
| Atamparib | ||
| Atamparib (RBN-2397) is a potent, orally active NAD+ competitive PARP7 inhibitor with an IC50 value of less than 3 nM. Atamparib (RBN-2397) can directly inhibit cell proliferation and restore type I interferon signaling by inhibiting PARP7 in tumor cells to stimulate innate or adaptive antitumor immune responses. | ||
| M11026 | CU-T12-9 | TLR |
| Cu-t12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM. Cu-t12-9 activates both the innate and adaptive immune systems. | ||
| M14658 | Barbadin | Apoptosis |
| Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. | ||
| M24900 | Orilanolimab | Others |
| SYNT001 | ||
| Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity. | ||
| M25047 | Sabatolimab | Others |
| MBG453 | ||
| Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells. | ||
| M25119 | Botensilimab | Others |
| AGEN 1181 | ||
| Botensilimab (AGEN 1181), a humanized anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer. | ||
| M28487 | LP-935509 | AAK1 |
| LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research. | ||
| M28593 | BMT-090605 | AAK1 |
| BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain. | ||
| M28772 | BMS-911172 | AAK1 |
| BMS-911172 is an adaptor associated kinase 1 (AAK1 kinase) inhibitor (IC50 = 35 nM). | ||
| M29394 | BMT-090605 hydrochloride | CDK |
| BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain. | ||
| M31031 | Apraglutide TFA | GLP Receptor |
| FE 203799 TFA | ||
| Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum. | ||
| M31380 | Recombinant Human HSP70 Protein (HEK293, N-His) | Recombinant Proteins |
| HSP70-2; HSP72; HSPA1 | ||
| HSP70 can serve a cytokine function to initiate both innate and adaptive immunity through activation of APC. HSP serves also a chaperone function and facilitates the presentation of antigen peptide to T cells. | ||
| M51624 | Protein Kinase C Peptide Substrate | Others |
| Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins. | ||
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