About 30 results found for searched term "C 87" (0.008 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1700 | Momelotinib (CYT387) | JAK |
| LM-1149; Momelotinib; CYT 11387 | ||
| Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. | ||
| M1705 | Erlotinib Hydrochloride | EGFR/HER2 |
| Tarceva, CP-358774, OSI-774, NSC-718781 | ||
| Erlotinib is an inhibitor of human EGFR tyrosine kinase (IC50 = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC50 = 20 nM). | ||
| M1714 | GDC-0879 | Raf |
| GDC-0879 is a potent and selective B-Raf kinase inhibitor with an EC50 of 0.75 µM. | ||
| M1788 | IC-87114 | PI3K |
| PIK-293; IC87114 | ||
| IC-87114 is a compound that inhibits the p110δ isoform of PI3K selectively, p110δ(IC50 = 0.13 µM) vs. p110α(IC50 = 200 µM), p110β(IC50 = 16 µM) and p110γ(IC50 = 61 µM). | ||
| M2057 | Dexrazoxane hydrochloride | Topoisomerase |
| Cardioxane, ICRF-187, NSC169780, Zinecard，DXZ | ||
| Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. | ||
| M2431 | b-AP15 | Deubiquitinase |
| NSC 687852 | ||
| b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M2541 | CRT0044876 | DNA/RNA Synthesis |
| NSC 69877 | ||
| CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. | ||
| M2578 | RITA | p53 |
| NSC 652287 | ||
| RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. | ||
| M2743 | GW2580 | CSF-1R (c-Fms) |
| SC-203877 | ||
| GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. | ||
| M3112 | Valdecoxib | COX |
| SC 65872 | ||
| Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM. | ||
| M3213 | Meclizine dihydrochloride | Histamine Receptor |
| Meclozine dihydrochloride; NSC28728 | ||
| Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR. Phase2. | ||
| M3476 | CEP-18770 | Proteasome |
| Delanzomib | ||
| CEP-18770 is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. | ||
| M3505 | Glipizide | Potassium Channel |
| CP 28720; K 4024 | ||
| Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. | ||
| M3792 | Vatalanib | VEGFR/PDGFR |
| CGP-7978, PTK 787, ZK222584 | ||
| Vatalanib is an inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. | ||
| M3901 | Combretastatin A4 | Microtubule |
| CRC 87-09, NSC 817373, CA-4 | ||
| Combretastatin A4 (CA-4), which is a natural stilbene isolated from Combretum caffrum, is a microtubule-destabilizing agent that binds to the colchicine domain on β-tubulin and exhibits a lower toxicity profile than paclitaxel or the Vinca alkaloids. | ||
| M3922 | Gracillin | STAT |
| NSC-698787 | ||
| Gracillin is a glycoside, more particularly to a Spirostanol saponin, which can be found among others in many plants of the genus Dioscorea, Paris and Costacea, for example in tamus communis. | ||
| M3971 | Isosteviol | ROS |
| Ketoisostevic Acid,NSC 231875 | ||
| Isosteviol is a tetracyclic diterpenoid obtained by acid hydrolysis of steviol glycoside extracts isolated from abundant Stevia rebaudiana plants. | ||
| M4638 | Pseudolaric-acid | Antibiotic |
| NSC615487 | ||
| Pseudolaric C is a diterpenoid acid isolated from the root bark of Pseudolarix Kaempferi Gorden with antifungal activity. | ||
| M4871 | CL-387785 | EGFR/HER2 |
| EKI-785 | ||
| CL-387785 (EKI-785) is an irreversible, and selective EGFR inhibitor with IC50 of 370 pM. | ||
| M5116 | Formoterol Hemifumarate | Adrenergic Receptor |
| Eformoterol, CGP 25827A, NSC 299587, YM 08316 | ||
| Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease. | ||
| M5166 | Conivaptan hydrochloride | Vasopressin Receptor |
| Conivaptan HCl, Vaprisol, YM 087 | ||
| Conivaptan hydrochloride is a non-peptide vasopressin receptor antagonist, which can inhibit V1A receptor in rat liver and V2 receptor in kidney with Ki values of 0.48 and 3.04 nM, respectively. | ||
| M5400 | Alosetron Hydrochloride | 5-HT Receptor |
| GR 68755C, GR 68755 Hydrochloride; GR 68755X Hydrochloride | ||
| Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. | ||
| M5611 | Embelin | IAP |
| Embelic acid; Emberine; NSC 91874 | ||
| Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide). | ||
| M5621 | Erlotinib (CP-358774) | EGFR/HER2 |
| CP358774; NSC 718781; OSI-774 | ||
| Erlotinib (CP-358774) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. | ||
| M5892 | Pramiracetam | Others |
| CI-879 | ||
| Pramiracetam is a more effective compound derived from Piracetam. | ||
| M6389 | 1-Aminobenzotriazole (ABT) | Cytochrome P450 (e.g. CYP17) |
| ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 | ||
| 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis. | ||
| M6806 | IC 87201 | Others |
| IC 87201 is a nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant. | ||
| M7059 | NSC-87877 | Phosphatase |
| NSC87877 | ||
| Nsc-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatase with IC50 values of 0.318 μM and 0.355 μM, respectively. Nsc-87877 also inhibits bispecific phosphatase 26 (DUSP26). | ||
| M7707 | CX546 | GluR |
| CX-546; GR-87 | ||
| CX546 is a selective positive AMPA glutamate receptor modulator. | ||
| M7734 | CP-24879 hydrochloride | Ferroptosis |
| CP-24879 hcl | ||
| CP-24879 hydrochloride is a potent, selective and combined delta5D/delta6D desaturase inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. | ||
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