About 16 results found for searched term "AR03" (0.059 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1733 | TG101348 | JAK |
| Fedratinib; SAR302503 | ||
| TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor with IC50 of 3 nM. | ||
| M2468 | Brimonidine Tartrate | Adrenergic Receptor |
| Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate | ||
| Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension. | ||
| M3708 | Anastrozole | Cytochrome P450 (e.g. CYP17) |
| Arimidex, ZD1033 | ||
| Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M8996 | SAR-20347 | JAK |
| SAR-20347 is a potent dual inhibitor of JAK1 and TYK2 with IC50 values of 23 and 0.6 nM, respectively. | ||
| M10492 | Ropivacaine | Animal experimental anesthetics |
| Narop; Noropine; LEA-103 | ||
| Ropivacaine is a member of the amino amide class of local anesthetics and acts as a potent sodium channel blocker. | ||
| M14813 | GPRP acetate | Peptides |
| Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate | ||
| GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa). | ||
| M21158 | Vepdegestrant (ARV-471) | PROTAC |
| ARV471; 2229711-08-2; PF-07850327 | ||
| Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer.ARV-471 is a heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes.ARV-471 causes ubiquitination and subsequent degradation of the estrogen receptor via the proteasome.ARV-471 potently degrades ER-positive The ER in breast cancer cell lines is potently degraded by ARV-471 with a DC50 value of approximately 2 nM. | ||
| M21828 | ARN1203 | Others |
| ARN1203 | ||
| M25008 | Itepekimab | IL Receptor/Related |
| REGN-3500; SAR-440340 | ||
| Itepekimab (REGN-3500) is a monoclonal antibody of IL-33. Itepekimab reduces airway inflammation and related tissue damage in previous clinical studies. Itepekimab has potential application in asthma, chronic obstructive pulmonary disease (COPD) and atopic dermatitis (AD). | ||
| M28083 | SAR-260301 | PI3K |
| SAR-260301 is an orally available and selective PI3Kβ inhibitor with an IC50 of 23 nM. | ||
| M28279 | Fedratinib hydrochloride hydrate | JAK |
| TG-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate | ||
| Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. | ||
| M28798 | ARN-6039 | ROR |
| ARN-6039 is an orally available inverse agonist of RORγ for autoimmune demyelinating disease. | ||
| M30213 | AR03 | DNA/RNA Synthesis |
| BMH-23 | ||
| AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells. | ||
| M30472 | GPRP | Integrin |
| Gly-Pro-Arg-Pro; Pefa 6003 | ||
| GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa). | ||
| M40626 | AR-13503 | ROCK |
| AR-13503 is an active metabolite of Netarsudil and a PKC/ROCK inhibitor that inhibits angiogenesis and enhances retinal pigment epithelium (RPE) permeability. It can be used in studies related to diabetic macular edema and macular degeneration. | ||
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