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SAR-260301 

Cat. No. M28083

All AbMole products are for research use only, cannot be used for human consumption.

SAR-260301  Structure

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Quality Control & Documentation
Biological Activity

SAR-260301 is an orally available and selective PI3Kβ inhibitor with an IC50 of 23 nM.

Chemical Information
Molecular Weight 354.4
Formula C19H22N4O3
CAS Number 1260612-13-2
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Philippe L Bédard, et al. Cancer. First-in-human trial of the PI3Kβ-selective inhibitor SAR260301 in patients with advanced solid tumors

[2] Hélène Bonnevaux, et al. Mol Cancer Ther. Concomitant Inhibition of PI3Kβ and BRAF or MEK in PTEN-Deficient/BRAF-Mutant Melanoma Treatment: Preclinical Assessment of SAR260301 Oral PI3Kβ-Selective Inhibitor

[3] Victor Certal, et al. J Med Chem. Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

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  Catalog
Abmole Inhibitor Catalog




Keywords: SAR-260301  supplier, PI3K, inhibitors, activators

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