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AR03

Cat. No. M30213
AR03 Structure
Synonym:

BMH-23

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Biological Activity

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.

Chemical Information
Molecular Weight 237.3
Formula C15H15N3
CAS Number 510721-85-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Johan S Hero, et al. Prep Biochem Biotechnol. Proteomic analysis of secretomes from Bacillus sp. AR03: characterization of enzymatic cocktails active on complex carbohydrates for xylooligosaccharides production

[2] Johan S Hero, et al. Prep Biochem Biotechnol. Endoglucanase and xylanase production by Bacillus sp. AR03 in co-culture

[3] Jing Wang, et al. Ying Yong Sheng Tai Xue Bao. [Inhibition of Bacillus pumilus AR03 on Alternaria alternata and Erysiphe cichoracearum on tobacco]

[4] Adriana P Manfredi, et al. Appl Biochem Biotechnol. Synergistic Effect of Simple Sugars and Carboxymethyl Cellulose on the Production of a Cellulolytic Cocktail from Bacillus sp. AR03 and Enzyme Activity Characterization

[5] Aditi Bapat, et al. J Pharmacol Exp Ther. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells

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Keywords: AR03, BMH-23 supplier, DNA/RNA Synthesis, inhibitors, activators

 
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