About 26 results found for searched term "APS-5" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29335 | APS6-45 | Ras |
| APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity. | ||
| M43825 | APS-5 | Fluorescent Dye |
| Lumigen APS-5 | ||
| APS-5 is a substrate of alkaline phosphatase (ALP). APS-5 can be used to assess the activity of alkaline phosphatase (ALP). | ||
| M2383 | AMG-517 | TRP Channel |
| AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. | ||
| M2753 | Hemicholinium 3 | AChR/AChE |
| Hemicholinium dibromide; HC-3 | ||
| Hemicholinium 3 is a compound which blocks the reuptake of choline by the high-affinity choline transporter (ChT) at the presynapse. Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. | ||
| M3537 | Suplatast Tosylate | IL Receptor/Related |
| IPD-1151T | ||
| Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. | ||
| M8747 | Synta66 | Calcium Channel |
| Synta66 (S66) is a CRAC (Ca2+ release-activated Ca2+) channel inhibitor that blocks SOCE (store-operated Ca2+ entry) upon Ca2+ depletion from intracellular stores by thapsigargin in human vascular smooth muscle cells (VSMCs) with high potency (IC50 = 26 nM & 43 nM based on maximum Ca2+ level & rate of increase, respectly). | ||
| M9112 | AB-423 | Anti-infection |
| AB-423 is an inhibitor of HBV capsid assembly, and potent inhibits HBV replication with EC50/EC90 of 0.08-0.27 μM/0.33-1.32 μM in cells. | ||
| M9119 | JNJ-632 | Anti-infection |
| JNJ632 | ||
| JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. | ||
| M21114 | Lenacapavir | HIV Protease |
| GS-6207 | ||
| Lenacapavir(GS-6207) is a first-in-class, long-acting HIV capsid inhibitor. Lenacapavir has anti-HIV activity with an EC50 of 100 pM in MT-4 cells and a mean EC50 of 50 pM (20-160 pM) against 23 clinical isolates of HIV-1 from different subtypes in peripheral blood mononuclear cells. | ||
| M21612 | Recombinant Mouse IFN-beta Protein (HEK293) | Cytokines and Growth Factors |
| IFN-beta; IFNB Protein | ||
| Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 3-18 pg/mL. | ||
| M21634 | TAPS | Others |
| TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH). | ||
| M27754 | V116517 | TRP Channel |
| V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid). V116517 can be used for the research of pain. | ||
| M29098 | APS-2-79 | MEK |
| APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. | ||
| M29144 | Claficapavir | HIV Protease |
| A1752 | ||
| Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1. | ||
| M29493 | BA-53038B | Anti-infection |
| BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B. | ||
| M30094 | Vapendavir | Anti-infection |
| BTA798 | ||
| Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains. | ||
| M30211 | Voacangine | TRP Channel |
| Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana. | ||
| M40056 | Icariside E5 | Others |
| Icariside E5 is a lignan glycoside isolated from the Capsicum annuum. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties. | ||
| M40754 | Lenacapavir sodium | HIV Protease |
| GS-6207 sodium | ||
| Lenacapavir sodium is a first-in-class, long-acting HIV capsid inhibitor. Lenacapavir sodium has anti-HIV activity with an EC50 of 100 pM in MT-4 cells and an average EC50 of 50 pM (20-160 pM) in peripheral blood mononuclear cells against 23 clinical isolates of HIV-1 from different subtypes. | ||
| M41164 | HEC72702 | Anti-infection |
| HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. | ||
| M41182 | HIV-1 capsid inhibitor 1 | Anti-infection |
| HIV-1 capsid inhibitor 1 is a potent HIV-1 Capsid inhibitor with an EC50 value of 3.13 µM. | ||
| M52422 | OM99-2 | Gamma-secretase/Beta-secretase |
| OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM. | ||
| M52424 | OM99-2 TFA | Gamma-secretase/Beta-secretase |
| OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM. | ||
| M55579 | GLP-26 | Anti-infection |
| GLP26 | ||
| GLP-26 is an HBV capsid assembly modulators (CAM), inhibits HBV DNA replication (IC50=3 nM) in Hep AD38 system, and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools. | ||
| M55895 | AZD5582 dihydrochloride | IAP |
| AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. | ||
| M55822 | PF-3450074 | Anti-infection |
| PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). | ||
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