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Recombinant Mouse IFN-beta Protein (HEK293)

Cat. No. M21612
Recombinant Mouse IFN-beta Protein (HEK293) Structure
Synonym:

IFN-beta; IFNB Protein

Size Price Availability Quantity
20ug USD 540  USD540 In stock
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Quality Control & Documentation
  • Purity: >90%, Endotoxin < 1.0 EU/ug
  • COA
  • MSDS
Biological Activity

Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis.

Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 3-18 pg/mL.

The recombinant mouse IFNB1 consists of 166 amino acids and has a calculated molecular mass of 20.3 kDa.

Lyophilized from sterile PBS, pH 7.4.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O to 250 μg/ml
Storage Stable for up to twelve months from date of receipt at -20℃ to -80℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kara J Mould, et al. Am J Respir Cell Mol Biol. Recombinant IFN-β for Postseptic Acute Lung Injury-What's the Mechanism?

[2] Leticia Corrales, et al. Cell Rep. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

[3] Lingyin Li, et al. Nat Chem Biol. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

[4] Campbell Kaynor, et al. J Interferon Cytokine Res. Direct evidence that IFN-beta functions as a tumor-suppressor protein

[5] M A Horisberger, et al. Pharmacol Ther. Interferon-alpha hybrids

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Keywords: Recombinant Mouse IFN-beta Protein (HEK293), IFN-beta; IFNB Protein supplier, Recombinant Proteins, inhibitors, activators


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