About 30 results found for searched term "AN-9" (0.019 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1656 | Tivozanib (AV-951) | VEGFR/PDGFR |
| KRN951; Tivozanib | ||
| AV-951 (Tivozanib) is a potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM respectively. | ||
| M1674 | BIBR 953 | Thrombopoietin/Thrombin |
| Dabigatran, Pradaxa; BIBR 953ZW | ||
| BIBR 953 (Dabigatran, Pradaxa) is an oral anticoagulant from the class of the direct thrombin inhibitors. | ||
| M1713 | GDC-0449 (Vismodegib) | Smo |
| Vismodegib, HhAntag691 | ||
| GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. | ||
| M1757 | XL-184 | c-Met |
| Cabozantinib, BMS-907351，Cabometyx | ||
| XL184 is a small molecule inhibits multiple receptor tyrosine kinases, specifically MET and VEGFR2 with IC50 values of 0.035 and 1.8 nM for VEGFR2 and Met respectively. | ||
| M1811 | Tivantinib (ARQ-197) | c-Met |
| Tivantinib, ARQ197 | ||
| Tivantinib (ARQ 197) is a selective and oral small-molecule inhibitor of c-Met with a minimal IC50 value of 0.1 μM. | ||
| M40779 | Recombinant Influenza B Hemagglutinin/HA Protein (HEK293, C-His) | Cytokines and Growth Factors |
| Recombinant Influenza B Hemagglutinin / HA Protein is a homotrimer that recognizes target cells in vertebrates and does so by binding to salivary acid-containing receptors on these cells. When it binds to the target cell, it causes the host inner membrane to fuse with the viral membrane, thereby facilitating the entry of the viral genome into the target cell. | ||
| M1956 | Apatinib mesylate | VEGFR/PDGFR |
| Rivoceranib mesylate; YN968D1 | ||
| Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM. | ||
| M2057 | Dexrazoxane hydrochloride | Topoisomerase |
| Cardioxane, ICRF-187, NSC169780, Zinecard，DXZ | ||
| Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. | ||
| M2155 | (1S-cis)-Milnacipran Hydrochloride | 5-HT Receptor |
| Levomilnacipran hydrochloride; F-2695 hydrochloride | ||
| (1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2220 | GDC-0941 Bimesylate | PI3K |
| Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt); GDC-0941 | ||
| GDC-0941 Bimesylate is the orally bioavailable bismesylate salt of a potent inhibitor of the class I phosphatidylinositol 3 kinase (PI3K). | ||
| M2230 | Agomelatine | Melatonin Receptor |
| Valdoxan; Melitor; S-20098 | ||
| Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. Agomelatine is also a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. | ||
| M2313 | Tirbanibulin (KX2-391) | Src-bcr-Abl |
| KX-01 | ||
| Tirbanibulin (KX2-391) is a First-in-Class, highly selective non ATP-competitive Src inhibitor with GI50 of 9-60 nM in cancer cell lines . | ||
| M15032 | Recombinant Human FGF-9 (E. coli) | Cytokines and Growth Factors |
| Fibroblast Growth Factor-9; FGF9 | ||
| Fibroblast Growth Factor-9 (FGF-9) is a heparin binding growth factor that belongs to the fibroblast growth factor (FGF) family. ED50 < 2.0 ng/ mL, determined by 3T3 cell proliferation assay, corresponding to > 5.0× 105 units/mg. | ||
| M11300 | Recombinant Human Apolipoprotein H/APOH (HEK293, His) | Cytokines and Growth Factors |
| Apolipoprotein H 蛋白, Human (HEK293, His) | ||
| Recombinant human Apolipoprotein H(APOH) protein (HEK293, His) was expressed in HEK293 cells with a His tag on the N-terminal. Apolipoprotein H is the primary target of antiphospholipid antibodies (aPLs) found in many patients with systemic lupus erythematosus and antiphospholipid syndrome (APS). | ||
| M3493 | Mitoxantrone | Topoisomerase |
| Mitozantrone; NSC 301739 | ||
| Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively | ||
| M40805 | Recombinant Human TPO (HEK293, N,C-6His) | Cytokines and Growth Factors |
| Thrombopoietin; THPO | ||
| Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. | ||
| M3933 | Danazol | Androgen Receptor |
| Danocrine, NSC 270916 | ||
| Danazol is a derivative of the synthetic steroid ethisterone that suppresses the production of gonadotrophins and has some weak androgenic effects. | ||
| M4553 | Tangeretin | Notch |
| Tangeritin; NSC53909; NSC618905; Ponkanetin | ||
| Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. | ||
| M4822 | Eltrombopag Olamine | Thrombopoietin/Thrombin |
| Eltrombopag diethanolamine salt; SB-497115GR | ||
| Eltrombopag olamine is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. | ||
| M4884 | Dalvance | Antibiotic |
| Dalbavancin; BI 397; MDL 63397 | ||
| Dalbavancin (Zeven, BI 397, MDL 63397) is a lipopeptide antibiotic with bactericidal activity against Gram-positive bacteria, such as a variety of staphylococcus. | ||
| M58149 | Recombinant Vaccinia virus B18R (HEK293, C-6His) | Cytokines and Growth Factors |
| Soluble interferon alpha/beta receptor B18; VACWR200 | ||
| B18R is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. | ||
| M5726 | Recombinant Human CD48/SLAMF2 (HEK293,C-Fc-6His) | Cytokines and Growth Factors |
| CD48 antigen; B-lymphocyte activation marker BLAST-1 | ||
| Recombinant human CD48/SLAMF2 protein plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma. | ||
| M5805 | Nandrolone | Androgen Receptor |
| Nandrolone, 19-Norandrostenolone, Norandrostenolone | ||
| Nandrolone is a synthetic, anabolic steroid analog of testosterone. | ||
| M6332 | 3-AP | DNA/RNA Synthesis |
| 3-AP; PAN-811; OCX191; NSC663249 | ||
| 3-AP is a ribonucleotide reductase inhibitor; also an iron chelator. | ||
| M6445 | ANR 94 | Adenosine Receptor |
| ANR 94 is a adenosine A 2A antagonist. | ||
| M6504 | Olcegepant (BIBN-4096) | CGRP Receptor |
| BIBN-4096; BIBN 4096BS | ||
| Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP. | ||
| M6804 | IBMX | PDE |
| IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964; 3-isobutyl-1-methylxanthine | ||
| IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. | ||
| M7609 | AN-9 | Others |
| HDAC inhibitors were tested as anticancer compounds; Butyric acid precursor compound. | ||
| M7706 | Chromanol 293B | Potassium Channel |
| Blocker of the slow delayed rectifier K+ current via KCNQ1 channels. | ||
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