About 16 results found for searched term "58-85-5" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2456 | Biotin | Others |
| Vitamin B7; Vitamin H; D-Biotin | ||
| Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. | ||
| M14892 | NVP-BHG712 isomer | Ephrin Receptor |
| NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4. | ||
| M2553 | GS-5885 | HCV Protease |
| Ledipasvir | ||
| GS-5885 is an inhibitor of the hepatitis C virus (HCV) NS5A protein and exhibits potent suppression of genotype 1 HCV replicons. | ||
| M5307 | Afatinib dimaleate | EGFR/HER2 |
| BIBW 2992MA2; BIBW2992; Afatinib | ||
| Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. | ||
| M6081 | EAI045 | EGFR/HER2 |
| EAI045 is a fourth generation allosteric inhibitor of mutant EGFR, which inhibits EGFR at 10 μM ATP, EGFRL858R, EGFRT790M and EGFRL858R/T790M with IC50 values of 1.9, 0.019, 0.19 and 0.002 μM respectively. | ||
| M7260 | SB 258585 hydrochloride | Others |
| SB 258585 hydrochloride is a potent, selective 5-HT 6 antagonist. | ||
| M11170 | NSC745885 | Apoptosis |
| NSC745885 is a potent anti-tumor reagent that is selectively toxic to a variety of cancer cell lines but not to normal cells. NSC745885 is a potent downregulator of EZH2 through the proteasome degradation pathway. NSC745885 offers the possibility of research on advanced bladder cancer and oral squamous cell carcinoma. | ||
| M20785 | Ledipasvir acetone | Anti-infection |
| GS-5885 acetone | ||
| Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively. | ||
| M27798 | SNT-207858 | Melanocortin Receptor |
| SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | ||
| M27800 | SNT-207858 free base | Melanocortin Receptor |
| SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | ||
| M27804 | BI-135585 | Hydroxysteroid dehydrogenase |
| BI-135585 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor with an IC50 of 13 nM. BI-135585 exhibits >1000-fold selectivity over other hydroxysteroid dehydrogenases. BI-135585 can be used for type 2 diabetes research. | ||
| M28183 | GSK5852 | Anti-infection |
| GSK2485852 | ||
| GSK5852 (GSK2485852) is an HCV NS5B polymerase inhibitor, with an IC50 value of 50 nM. GSK5852 displays antiviral activity and inhibits HCV with EC50s of 3.0 nM (genotype 1a, GT1a) and 1.7 nM (GT1b), respectively. | ||
| M28438 | L685818 | Antifungal |
| L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans. | ||
| M29151 | JBJ-04-125-02 | EGFR/HER2 |
| JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities. | ||
| M30090 | PC58538 | Antibiotic |
| PC58538 is a cell division inhibitor, targeting to FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis. PC58538 is also known to modulate the rate of GTP hydrolysis. | ||
| M42077 | EGFR T790M/L858R-IN-2 | EGFR/HER2 |
| EGFRT790M/L858R-IN-2 is a potent and selective EGFRT790M/L858R inhibitor with IC50 values of 3.5, 1290 nM for EGFRT790M/L858R, EGFR WT, respectively. | ||
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