About 33 results found for searched term "57-50-1" (0.071 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9993 | Sucrose | Solvents & Excipients |
| Sucrose can be used to make citric acid, caramel, invert sugar, transparent soap and so on. Sucrose can inhibit bacterial growth in high concentration, and can be used as preservative and antioxidant excipient in medicine. | ||
| M19204 | Crocin III | Others |
| Crocin III is a crocetin from saffron (Crocus sutivus L.). Crocetins inhibit cell growth of tumor cells and has anti-inflammatory activity. Crocins serve as spices and coloring agents. | ||
| M31221 | Laropiprant sodium | Prostaglandin Receptor |
| Laropiprant sodium is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively. | ||
| M1730 | Givinostat hydrochloride monohydrate | HDAC |
| ITF-2357 hydrochloride monohydrate | ||
| ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. | ||
| M1759 | GSK1120212 (Trametinib) | MEK |
| JTP-74057, GSK212 | ||
| Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. | ||
| M1809 | NU7441 | PI3K |
| KU 57788 | ||
| NU7441 (KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 values of 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. | ||
| M9217 | Givinostat | HDAC |
| ITF2357 | ||
| Givinostat (ITF-2357) is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M1847 | Fostamatinib disodium | Syk |
| R788 Disodium; R-935788 Disodium | ||
| Fostamatinib disodium (R788, R-935788) is a potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor with IC50 of 41 nM. | ||
| M1994 | Telatinib | VEGFR/PDGFR |
| BAY 57-9352 | ||
| Telatinib (BAY 57-9352) is an orally active small-molecule tyrosine kinase inhibitor of VEGFR2, VEGFR3 and PDGFRβ with IC50 of 6 nM, 4 nM and 15 nM, respectively. | ||
| M2130 | LY-411575 | Gamma-secretase/Beta-secretase |
| LSN-411575 | ||
| LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. | ||
| M11172 | Reslizumab | IL Receptor/Related |
| Sch 55700 | ||
| Reslizumab (Sch 55700) is a humanized monoclonal antibody targeting human interleukin 5 (IL-5) for the study of eosinophilic asthma. Reslizumab effectively blocks il-5 function. Reslizumab inhibited IL-5-dependent cell proliferation with an IC50 of about 91.1 pM. | ||
| M2506 | CGP 57380 | MNK |
| CGP 57380 is potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. | ||
| M2869 | MRS 2578 | P2 Receptor |
| MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. | ||
| M2931 | PF-573228 | FAK |
| PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. | ||
| M11368 | STM2457 | METTL3 |
| STM2457 is a first-in-class, potent and specific, orally active METTL3 inhibitor with an IC50 of 16.9 nM and excellent in vivo activity without off-target effects. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M3517 | Lapatinib | EGFR/HER2 |
| GW-572016; GW2016 | ||
| Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. | ||
| M3640 | BAY 57-1293 | Anti-infection |
| Pritelivir; AIC316 | ||
| BAY 57-1293 is a potent helicase primase inhibitor that exhibites antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. | ||
| M3765 | NVP-QAV-572 | PI3K |
| NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM. | ||
| M4532 | Rhodionin | AChR/AChE |
| Rhodionin was isolated from the roots of Rhodiola crenulata and is a specific non-competitive cytochrome P450 2D6 inhibitor with IC50 of 0.761 μM and Ki of 0.769 μM. Rhodionin effectively inhibited acetylcholinesterase (AChE) in a dose-dependent manner with an IC50 range of 57.50 to 2.43 μg/mL. Rhodionin had effective DPPH radical scavenging activity with IC50 of 19.49 μM. | ||
| M4831 | GSK2578215A | LRRK2 |
| GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. | ||
| M4940 | SC75741 | NF-κB |
| SC-75741 | ||
| SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. | ||
| M5210 | GSK1325756 (Danirixin) | CXCR |
| Danirixin | ||
| GSK1325756 (Danirixin) is a non-peptide, high affinity, selective and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8. | ||
| M6137 | PF-05175157 | Acetyl-CoA Carboxylase |
| PF-05175157 (Compound 9) is a potent Acetyl-CoA carboxylase (ACC1) inhibitor with IC50s of 23.5±1.1 nM (rat) and 27.0±2.7 nM (human). | ||
| M6466 | AS 1269574 | GPR/FFAR |
| AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research. | ||
| M7877 | KT 5720 | PKA |
| KT 5720 is a specific, reversible, ATP-competitive, cell-permeable protein kinase A (PKA) inhibitor with an IC50 value of 3.3 μM, which effectively reverses MDR1-mediated multidrug resistance and reduces excitability of dorsal root ganglion (DRG) neurons by attenuating the activity of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and decreasing the intracellular Ca2+ concentration. ) neurons by reducing hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel activity and intracellular Ca2+ concentration. It can be used in the study of hematologic malignancies and diseases associated with HCN and DRG neurons. | ||
| M9248 | CID5721353 | Bcl-2 |
| BCL6 Inhibitor | ||
| CID5721353 is a B-Cell Lymphoma 6 inhibitor with IC50 of 212 μM. | ||
| M9622 | BAY-1143572 Racemate | CDK |
| Atuveciclib Racemate | ||
| BAY-1143572 Racemate (Atuveciclib Racemate) is the racemate mixture of Atuveciclib, Atuveciclib is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM. | ||
| M9711 | AG1557 | EGFR/HER2 |
| AG-1557 | ||
| AG1557 is a potent and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with pIC50 value of 8.194. | ||
| M10129 | CCT245737 | Checkpoint |
| SRA737; PNT-737 | ||
| CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor, with IC50 values of 1.3 nM, 2440 nM and 30 nM for CHK1, CHK2 and G2 check point abrogation, respectively. | ||
| M10157 | Seletalisib | PI3K |
| UCB5857 | ||
| Seletalisib (UCB5857) is a potent and selective PI3Kδ inhibitor, with IC50 of 12 nM. | ||
| M10476 | GDC-0575 (ARRY-575) | Checkpoint |
| RG7741; ARRY575; AK-687476 | ||
| GDC-0575 (ARRY-575, RG7741) is a potent and selective oral inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. | ||
| M10634 | NE 52-QQ57 | GPR/FFAR |
| NE52QQ57 | ||
| NE 52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2). | ||
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