About 21 results found for searched term "5-LOX-IN-2" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5370 | 5,5-Dimethyloxazolidine-2,4-dione | Metabolite/Endogenous Metabolite |
| Dimethadione, Dimethyloxazolidinedione, Dimethadion | ||
| Dimethadione is an anticonvulsant that is the active metabolite of trimethadione. | ||
| M6038 | Trimethadione | Calcium Channel |
| 3,5,5,-Trimethyloxazolidine-2,4-dione | ||
| Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions. | ||
| M42005 | COX-2/15-LOX-IN-2 | Lipoxygenase |
| COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065?μM and 1.86?μM, respectively. | ||
| M42481 | 5-LOX-IN-2 | Lipoxygenase |
| 5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . | ||
| M2332 | Zileuton | Lipoxygenase |
| A 64077; Abbott 64077 | ||
| Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis with IC50 values of 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively. | ||
| M6394 | AC 45594 | Anti-infection |
| 4-Heptyloxyphenol | ||
| AC 45594 is a sF-1 inverse agonist. 4-Heptyloxyphenol (AC 45594) has antibacterial activity agaisnt P. gingivalis, S. artemidis, Str. sobrinus (MIC: 0.10, 0.21, 0.14 mM). | ||
| M8506 | ML351 | Lipoxygenase |
| ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. | ||
| M10956 | PAT-1251 | Monoamine Oxidase |
| PAT-1251 is a potent, selective, orally lysanyl oxidase-like protein 2 (LOXL2) inhibitor of hLOXL2 and hLOXL3 IC50 The values were 0.71 and 1.17 μM, respectively, and the inhibition of LOXL2 in mice, rats, and dogs was strong.IC50 Values are 0.10, 0.12, and 0.16 μM, respectively; PAT-1251 can be used for studies of a variety of fibrous diseases. | ||
| M11173 | PC945 | Others |
| PC945 is a potent antifungal triazole drug that is resistant to a variety of sensitive and resistant strains of Aspergillus fumigatus. PC945 is a potent, tightly bound inhibitor of aspergilloxine 14α-demethylase (CYP51A/CYP51B) activity.IC50s are 0.23 μM and 0.22 μM, respectively. | ||
| M14458 | 5-O-Demethylnobiletin | Lipoxygenase |
| 5-Demethylnobiletin | ||
| 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. | ||
| M29270 | PXS-5153A | Monoamine Oxidase |
| PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis. | ||
| M29273 | CCT365623 hydrochloride | Monoamine Oxidase |
| CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor, with an IC50 of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF. CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties. | ||
| M31063 | PXS-5153A monohydrochloride | Monoamine Oxidase |
| PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis. | ||
| M40148 | 1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine | Others |
| 1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine is an oxoaporphine alkaloid. 1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine can be isolated from Thalictrum elegans. | ||
| M41634 | DKI5 | Others |
| DKI5, also known as (E)-N’-benzylidenehydrazinecarbothiohydrazide, is a LOX-1 inhibitor with an IC50 value of 22.5 μM. | ||
| M42482 | h15-LOX-2 inhibitor 1 | Lipoxygenase |
| h15-LOX-2 inhibitor 1 is a human epithelial 15-lipoxygenase-2 (h15-LOX-2) inhibitor with IC50 of 0.34 μM. | ||
| M42483 | MLS000545091 | Lipoxygenase |
| MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC50 value of 2.6 μM for h15-LOX-2. | ||
| M42484 | COX-2/15-LOX-IN-3 | Lipoxygenase |
| COX-2/15-LOX-IN-3 is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. | ||
| M42485 | COX-2/15-LOX-IN-4 | Lipoxygenase |
| COX-2/15-LOX-IN-4 is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. | ||
| M45337 | ALOX15-IN-2 | Lipoxygenase |
| ALOX15-IN-2 is a potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50s of 1.55 and 2.79 μM for linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, respectively. | ||
| M56711 | 5-LOX-IN-1 | Lipoxygenase |
| 5-LOX-IN-1 is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. | ||
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