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PC945

Cat. No. M11173

All AbMole products are for research use only, cannot be used for human consumption.

PC945 Structure

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Quality Control & Documentation
Biological Activity

PC945 is a potent antifungal triazole drug that is resistant to a variety of sensitive and resistant strains of Aspergillus fumigatus. PC945 is a potent, tightly bound inhibitor of aspergilloxine 14α-demethylase (CYP51A/CYP51B) activity.IC50s are 0.23 μM and 0.22 μM, respectively.

Chemical Information
Molecular Weight 682.75
Formula C38H37F3N6O3
CAS Number 1931946-73-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kazuhiro Ito, et al. Eur J Pharm Sci. Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice: Pulmonary PK-PD analysis of anti-fungal PC945

[2] Alison Murray, et al. J Fungi (Basel). PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections

[3] Shivaprakash M Rudramurthy, et al. J Antimicrob Chemother. In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris

[4] Thomas Colley, et al. Sci Rep. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection

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Keywords: PC945 supplier, inhibitors, activators

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