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VU6001966 

Cat. No. M29103

All AbMole products are for research use only, cannot be used for human consumption.

VU6001966  Structure

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Quality Control & Documentation
Biological Activity

VU6001966 (compound 15m) is a potent and cross the blood-brain barrier mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator with IC50s of 78 nM and >30 µM for mGlu2 and mGlu3, respectively. VU6001966 can serve as an mGlu2 PET tracer.

Chemical Information
Molecular Weight 326.33
Formula C17H15FN4O2
CAS Number 2009052-76-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Gengyang Yuan, et al. J Med Chem. Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2 H-pyrano[2,3- b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

[2] Katrina A Bollinger, et al. ACS Med Chem Lett. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core

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  Catalog
Abmole Inhibitor Catalog




Keywords: VU6001966  supplier, GluR, inhibitors, activators

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