Free shipping on all orders over $ 500

TMC310911

Cat. No. M27589

All AbMole products are for research use only, cannot be used for human consumption.

TMC310911 Structure
Synonym:

ASC-09

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity.

Chemical Information
Molecular Weight 755.99
Formula C38H53N5O7S2
CAS Number 1000287-05-7
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Soodeh Mahdian, et al. J Diabetes Metab Disord. Drυg repurposing using computational methods to identify therapeutic options for COVID-19

[2] Iruthayaraj Ancy, et al. J Biomol Struct Dyn. Possibility of HIV-1 protease inhibitors-clinical trial drυgs as repurposed drυgs for SARS-CoV-2 main protease: a molecular docking, molecular dynamics and binding free energy simulation study

[3] Richard M W Hoetelmans, et al. J Acquir Immune Defic Syndr. Safety and pharmacokinetics of the HIV-1 protease inhibitor TMC310911 coadministered with ritonavir in healthy participants: results from 2 phase 1 studies

[4] Hans-Jürgen Stellbrink, et al. J Acquir Immune Defic Syndr. Antiviral activity, pharmacokinetics, and safety of the HIV-1 protease inhibitor TMC310911, coadministered with ritonavir, in treatment-naive HIV-1-infected patients

[5] Inge Dierynck, et al. Antimicrob Agents Chemother. TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors

Related HIV Protease Products
Ritonavir-13c,d3

Ritonavir-13c,d3
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease.
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease.
HIV-1, HIV-2 Protease Substrate

HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease.
HIV Protease Substrate IV

HIV Protease Substrate IV is a substrate of HIV protease.
  Catalog
Abmole Inhibitor Catalog




Keywords: TMC310911, ASC-09 supplier, HIV Protease, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.