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Tiapride Hydrochloride

Cat. No. M20665
Tiapride Hydrochloride Structure
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Biological Activity

Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.

Chemical Information
Molecular Weight 364.89
Formula C15H25ClN2O4S
CAS Number 51012-33-0
Solubility (25°C) DMSO 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stephanie Feleus, et al. J Pers Med. The Many Faces of Huntington's Chorea Treatment: The Impact of Sudden Withdrawal of Tiapride after 40 Years of Use and a Systematic Review

[2] Caroline Zangani, et al. Hum Psychopharmacol. Efficacy of tiapride in the treatment of psychiatric disorders: A systematic review

[3] R Heun, et al. Eur Psychiatry. Tiapride in gerontopsychiatry

[4] J W Steele, et al. Drugs Aging. Tiapride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in geriatric agitation

[5] D H Peters, et al. Drugs. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome

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