Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
|Solubility (25°C)||DMSO 35 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Stephanie Feleus, et al. J Pers Med. The Many Faces of Huntington's Chorea Treatment: The Impact of Sudden Withdrawal of Tiapride after 40 Years of Use and a Systematic Review
 Caroline Zangani, et al. Hum Psychopharmacol. Efficacy of tiapride in the treatment of psychiatric disorders: A systematic review
 R Heun, et al. Eur Psychiatry. Tiapride in gerontopsychiatry
 J W Steele, et al. Drugs Aging. Tiapride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in geriatric agitation
 D H Peters, et al. Drugs. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome
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