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Teropavimab

Cat. No. M25140
Teropavimab Structure
Synonym:

3BNC117-LS; GS-5423

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Quality Control & Documentation
Biological Activity

Teropavimab (3BNC117-LS) is an antibody. Teropavimab can be used for the research of HIV infection.

Chemical Information
CAS Number 2417213-72-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daniel R Kuritzkes. Curr Opin HIV AIDS. Broadly neutralizing antibodies and long-acting antiretroviral drυgs as treatments for HIV

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Keywords: Teropavimab, 3BNC117-LS; GS-5423 supplier, HIV Protease, inhibitors, activators


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