Tenacissoside G is a C21 steroid from the stem of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in multidrug resistant cancer cells that overexpress p-glycoprotein (Pgp).
|Solubility (25°C)||DMSO ≥ 60 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related P-glycoprotein Products|
|P-gp inhibitor 13
P-gp inhibitor 13 is a P-gp inhibitor.
ABCB1-IN-1 is a potent ABCB1 inhibitor.
|P-gp inhibitor 14
P-gp inhibitor 14 is a high affinity P-gp inhibitor.
FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM).
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.