About 33 results found for searched term "P-glycoprotein" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21644 | Recombinant Human Fetuin A (HEK293, C-6His) | Cytokines and Growth Factors |
| FETUA; AHSG; Alpha-2-HS-Glycoprotein | ||
| Recombinant Human Fetuin A (AHSG) is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. AHSG is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. | ||
| M51671 | HHV-2 Envelope Glycoprotein G (552-574) | Others |
| HHV-2 Envelope Glycoprotein G (552-574) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera. | ||
| M53455 | FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) | Anti-infection |
| FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a FITC labeled HHV-2 Envelope Glycoprotein G (561-578). | ||
| M1657 | Atazanavir Sulfate | HIV Protease |
| BMS-232632, Reyataz, CGP-73547 | ||
| Atazanavir sulfate (BMS-232632, Reyataz) is an azapeptide inhibitor of HIV-1 protease. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M11352 | Coniferyl ferulate | Others |
| Coniferyl ferulate is a potent glutathione S-transferase (GST) inhibitor that reverses multidrug resistance and down-regulates p-glycoprotein. Coniferyl ferulate strongly inhibited human placental glutathione S-transferase with IC50 of 0.3 μM. | ||
| M1845 | LY335979 trihydrochloride | P-glycoprotein |
| Zosuquidar trihydrochloride; RS 33295-198 trihydrochloride | ||
| LY335979 (Zosuquidar trihydrochloride) is a selective Pgp (P-glycoprotein) inhibitor with a Ki of 59 nM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1853 | Biricodar | P-glycoprotein |
| VX-710, Incel | ||
| The pipecolinate derivative Biricodar (VX-710, Incel) is a clinically applicable modulator of P-glycoprotein (Pgp) with potential chemosensitizing activity. | ||
| M1888 | Tariquidar | P-glycoprotein |
| XR9576 | ||
| Tariquidar (XR9576) is a selective, highly efficacious third generation P-glycoprotein (P-gp) inhibitor. | ||
| M3118 | Verapamil hydrochloride | Calcium Channel |
| (±)-Verapamil hydrochlorid; CP-16533-1 hydrochloride | ||
| Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. Verapamil hydrochloride is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. | ||
| M3547 | Glibenclamide | Others |
| Glyburide; RP-1127; BIIB093 | ||
| Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). | ||
| M3847 | Alemtuzumab | Others |
| Campath-1H | ||
| Alemtuzumab is a recombinant DNA-derived humanized IgG1 kappa monoclonal antibody that is directed against the 21-28 kDa cell surface glycoprotein CD52. Alemtuzumab does not cross-react with mouse CD52, making in vivo studies in wild-type mice unfeasible. | ||
| M40805 | Recombinant Human TPO (HEK293, N,C-6His) | Cytokines and Growth Factors |
| Thrombopoietin; THPO | ||
| Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. | ||
| M4249 | Schisandrol B | NF-κB |
| Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B | ||
| Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities. | ||
| M4298 | Tenacissoside-G | P-glycoprotein |
| Tenacissoside G is a C21 steroid from the stem of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in multidrug resistant cancer cells that overexpress p-glycoprotein (Pgp). | ||
| M4886 | Selamectin | Parasite |
| Selamectin is an antiparasitic agent and insect repellent that activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent filariasis, lymphatic filariasis and nematode infection. Selamectin is also an effective p-glycoprotein substrate and inhibitor with IC50 of 120 nM. | ||
| M5068 | ELR510444 | Microtubule |
| ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. | ||
| M5375 | 6-Mercaptopurine (6-MP) Monohydrate | DNA/RNA Synthesis |
| 6-MP | ||
| Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting phosphoribose pyrophosphate amide transferase (PRPP amide transferase). PRPP amide transferase is a rate-limiting enzyme formed by purine. It alters the synthesis and function of RNA and DNA. Mercaptopurine also interferes with nucleoside tautomies and glycoprotein synthesis. | ||
| M5427 | Atazanavir | HIV Protease |
| BMS-232632; Latazanavir; Zrivada; Reyataz | ||
| Atazanavir (BMS-232632) is an azapeptide and HIV-protease inhibitor. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M5619 | Eptifibatide | Integrin |
| MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2; {MPA}{HAR}GDWPC-NH2 | ||
| Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. | ||
| M5935 | Risperidone | 5-HT Receptor |
| R-64766 | ||
| Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. | ||
| M6018 | Tirofiban hydrochloride monohydrate | Integrin |
| Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist | ||
| M6240 | Angiotensin II human | Animal Modeling |
| Angiotensin II; Hypertensin II; Ang II; DRVYIHPF | ||
| Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. | ||
| M6267 | Valspodar | P-glycoprotein |
| PSC 833 | ||
| Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator. | ||
| M8591 | LMT-28 | IL Receptor/Related |
| LMT28 | ||
| LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). | ||
| M8724 | NSC73306 | Others |
| NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. | ||
| M9241 | Recombinant Human EPO Protein (CHO) | Cytokines and Growth Factors |
| Erythropoietin | ||
| Erythropoietin (EPO) is a glycoprotein hormone known primarily for its role in erythropoiesis, which is responsible for stimulating the proliferation and differentiation of erythroid progenitor cells. | ||
| M9760 | Chicken egg albumin | Animal Modeling |
| Ovalbumin; OVA | ||
| Chicken egg albumin, or ovalbumin, is the major protein constituent of egg whites. Chicken egg albumin is a phosphorylated glycoprotein. | ||
| M9844 | Recombinant Human TPO Protein (HEK293, C-Fc) | Cytokines and Growth Factors |
| recombined human thrombopoietin; rhTPO; rhTHPO | ||
| Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. | ||
| M10000 | Recombinant Human Vitronectin Protein | Cytokines and Growth Factors |
| VTN-N | ||
| Recombinant Human Vitronectin Protein is a secreted glycoprotein synthesized in the liver. It mainly circulates in the form of monomers, but can undergo conformational changes to form disulfide bond-connected multimers. | ||
| M10007 | Recombinant Human Holo-Transferrin Protein | Cytokines and Growth Factors |
| Transferrin is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. | ||
| M10009 | Recombinant Human Apo-transferrin Protein | Cytokines and Growth Factors |
| Transferrin is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. | ||
| M10016 | Recombinant Rat EGF Protein (CHO) | Cytokines and Growth Factors |
| Epidermal Growth Factor | ||
| Recombinant Rat EGF Protein is type Itransmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. | ||
| M10075 | (+)-Biotinamidohexanoic acid hydrazide | Others |
| Biotin LC hydrazide | ||
| Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins. | ||
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