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Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
In vitro: Sinapine plays an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells. Sinapine can effectively protect against ·OH-induced damage to DNA and MSCs. Sinapine promotes doxorubicin accumulation in Caco-2 cell by inducing P-gp decrease. Sinapine significantly reduces phosphorylation of FRS2α, ERK1/2. Sinapine sensitive effects may occur through the suppression FGFR4-FRS2α-ERK1/2 signal pathway.
| Molecular Weight | 368.45 |
| Formula | C17H24N2O5S |
| CAS Number | 7431-77-8 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
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