Free shipping on all orders over $ 500


Cat. No. M1888
Tariquidar Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 47.7  USD53 In stock
10mg USD 81  USD90 In stock
25mg USD 139.5  USD155 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Tariquidar is a highly selective, potent non-competitive inhibitor of P-glycoprotein. P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring the multidrug resistance phenotype in cancer. P-gp is also expressed in normal tissues like blood brain barrier, gastrointestinal track, liver, spleen and kidney. Tariquidar profoundly inhibited P-glycoprotein in lymphocytes by 93.7% (95% confidence interval, 92.0-95.3%). Tariquidar (XR9576) inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from both inhibition of substrate binding and inhibition of ATP hydrolysis or each of them.

Customer Product Validations & Biological Datas
Source J Biol Chem (2015). Figure 3. Tariquidar
Method Disulfide Cross-linking Analysis
Cell Lines HEK 293 cells
Concentrations 0.5 μM
Incubation Time 16 h
Results Accordingly, we screened the rescue of 223 G251V processing mutants in which each position in the TM segment was replaced with arginine. HEK293 cells were transfected with each mutant and expressed for 16 h in the absence or presence of 0.5 μM tariquidar.
Source J Biol Chem (2015). Figure 2. Tariquidar
Method Expression and Maturation of G251V Arginine Mutants
Cell Lines HEK 293 cells
Concentrations 500, 1000 nM
Incubation Time 16 h
Results By contrast, a higher concentration (1000 nM) of tariquidar did not significantly inhibit cross-linking of the ICL (L175C(ICL1)/N820C(ICL3), A259C(ICL2)/W803C(ICL3), A266C(ICL2/F1086C(NBD2)) (Fig. 2B) or the NBD (C431(NBD1)/L1176C(NBD2), L531C(NBD1)/C1074(NBD2), and P517C(NBD1)/I1050C(NBD2)) mutants (Fig. 2C).
Cell Experiment
Cell lines HEK 293 cells
Preparation method A sample of the isolated histidine-tagged P-gp was mixed with an equal volume of 10 mg/ml of sheep brain phosphatidylethanolamine that had been washed and suspended in TBS. ATPase activity was measured in the presence of various concentrations of tariquidar.
Concentrations 0.25 µM, 0.5 µM, 1 µM,
Incubation time 24 h
Animal Experiment
Animal models Balb/C mice
Formulation water with 5% glucose
Dosages 10 mg/kg
Administration oral gavage
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 646.73
Formula C38H38N4O6
CAS Number 206873-63-4
Purity >98.5%
Solubility DMSO 100 mg/mL
Storage at -20°C

Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes.
Patel NR, et al. Int J Pharm. 2011 Sep 15;416(1):296-9. PMID: 21703341.

Related P-gp Products
Elacridar hydrochloride

Elacridar hydrochloride is a p-gp inhibitor.


Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator.


Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

Polyoxyethylene stearate

Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.

Abmole Inhibitor Catalog 2017

Keywords: Tariquidar, XR9576 supplier, P-gp, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.