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-Protopanaxadiol-chemical-structure.gif)
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. 20S-protopanaxadiol treatment upregulates the flotillin-1 level in the rafts of N2a cells to 142.91±10.71% of the control. 20S-protopanaxadiol can have an opposite effect on raft resident protein flotillin-1, depending on the cell type.
| Molecular Weight | 460.74 |
| Formula | C30H52O3 |
| CAS Number | 30636-90-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 46 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related P-glycoprotein Products |
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Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). |
| Tariquidar dimesylate
Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. |
| Tariquidar dihydrochloride
Tariquidar dihydrochloride (XR9576 dihydrochloride) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM). |
| Reversin 121
Reversin 121 is a P-glycoprotein inhibitor. |
| Reversin 205
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. |
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